王林波，博士，浙江大学医学院附属邵逸夫医院肿瘤外科主任医师，副教授。

 

1. 2014-09至2015-08, 加拿大蒙特利大学医学中心, 访问学者, 进修

2. 2001-10至2002-01, 美国罗玛琳达大学医学中心, 肿瘤外科进修, 进修

3. 1996-09至2000-06, 浙江大学医学院, 肿瘤学,博士,导师：郑树

4. 1993-09至1996-09, 浙江大学医学院, 肿瘤学,硕士,导师：郑树

5. 1981-09至1987-07, 中山医科大学, 临床医学, 本科

 

1. 2021年国家发明专利：人乳腺癌胸水转移细胞系即应用，ZL 2021 1 0287092.6, 1/12

2. 2020年浙江省科学技术进步二等奖：乳腺癌靶向诊疗新技术研究, 2020-J-2-002-R02

3. 2019年实用新型专利：乳腺活检残腔精准定位器, ZL 2019 2 0402268.6, 1/2

4. 2014年中国抗癌协会科技奖三等奖：乳腺癌化疗耐药的临床及基础研究, K-1302-3-11-1

5. 2011年浙江省科学技术进步奖三等奖：雌激素受体介导乳腺癌化疗耐药的研究，1/7

6. 2005年国家科学技术进步奖,二等奖：我国大肠癌高危人群防治的基础与临床应用研究, 排名9

7. 2005年浙江省科学技术进步奖三等奖：前哨淋巴结定位活检技术在大肠癌、胃癌及乳腺癌中的应用

 

1. 中国抗癌协会中西医整合肿瘤专业委员会常委（2018-08--至今）

2. 浙江省抗癌协会乳腺癌分会主任委员、委员（2013-2017）

3. 浙江省医学会肿瘤外科学分会副主任委员

4. 中国抗癌协会乳腺癌分会委员（2012-2016）

5. 浙江省抗癌协会理事（2002-2017）

6. 浙江省肿瘤防治办公室副主任（1995-2009）

 

1. 国家自然科学基金面上项目：KLF4介导铁死亡调控乳腺癌他莫昔芬耐药。主持，在研。

2. 浙江省自然科学基金一般项目：LncRNA H19介导的铁凋亡-自噬crosstalk调控乳腺癌他莫昔芬耐药。主持，已结题。

3. 国家自然科学基金面上项目：长链非编码RNA H19诱导自噬在乳腺癌他莫昔芬耐药中的作用。主持，已结题。

4. 004-“973”计划（01-国家科技部）：基于影像实时动态多元分子分型的乳腺癌精准治疗疗效评估和诊疗一体化研究。子课题负责人，已结题。

5. 030-博士点基金（08-国家教育部）：雌激素浓度与乳腺癌化疗耐药的研究。主持，已结题。

 

1. Ling Xu, Yixin Zhou, Lijie Chen, Abdul Saad Bissessur, Jida Chen, Misha Mao, Siwei Ju, Lini Chen,  Cong Chen,  Zhaoqin Li, Xun Zhang, Fei Chen, Feilin Cao, Linbo Wang and Qinchuan Wang. Deoxyribonucleic Acid 5-Hydroxymethylation in Cell-Free Deoxyribonucleic Acid, a Novel Cancer Biomarker in the Era of Precision Medicine. Front Cell Dev Biol. 2021; 9: 744990. IF=5.201.

2. Misha Mao, Yifan Cheng, Jingjing Yang, Yongxia Chen, Ling Xu, Xun Zhang, Zhaoqing Li, Cong Chen, Siwei Ju, Jichun Zhou and Linbo Wang. Multifaced roles of PLAC8 in cancer. Biomark Res 2021 Oct 09;9(1). IF=6.148.

3. Li Z, Chen C, Chen L, Hu D, Yang X, Zhuo W, Chen Y, Yang J, Zhou Y, Mao M, Zhang X, Xu L, Ju S, Shen J, Wang Q, Dong M, Xie S, Wei Q, Jia Y, Zhou J, Wang L. STAT5a Confers Doxorubicin Resistance to Breast Cancer by Regulating ABCB1. Front Oncol. 2021 Jul 15;11:697950. IF=6.244.

4. Jingjing Yang, Yulu Zhou, Shuduo Xie , Ji Wang, Zhaoqing Li, Lini Chen, Misha Mao, Cong Chen, Aihua Huang, Yongxia Chen, Xun Zhang, Noor Ul Hassan Khan, Linbo Wang, Jichun Zhou. Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer. J Exp Clin Cancer Res. 2021 Jun 23;40(1):206. IF=11.161.

5. Yongxia Chen, Yunlu Jia, Misha Mao, Yifeng Gu, Chenpu Xu, Jingjing Yang, Wenxian Hu, Jun Shen, Dengdi Hu, Cong Chen, Zhaoqing Li, Lini Chen, Jian Ruan, Peng Shen, Jichun Zhou, Qun Wei, Linbo Wang. PLAC8 promotes adriamycin resistance via blocking autophagy in breast cancer. J Cell Mol Med. 2021 Jun 11. IF=5.31.

6. Zhaoqing Li, Wenying Zhuo, Lini Chen, Xun Zhang, Cong Chen, Dengdi Hu, Yongxia Chen, Jingjing Yang, Yulu Zhou, Misha Mao, Ling Xu, Siwei Ju, Jun Shen, Qinchuan Wang, Minjun Dong, Shuduo Xie, Jichun Zhou, Linbo Wang. Establishment and Characterization of a HER2-Positive Cell Line Derived From the Pleural Effusion of a Drug-Resistant Breast Cancer Patient. Front Cell Dev Biol. 2021 Jun 1;9:680968. IF=6.684.

7. Misha Mao, Dengdi Hu, Jingjing Yang, Yongxia Chen, Xun Zhang, Jianguo Shen, Rongyue Teng, Jichun Zhou, Linbo Wang. Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change. J Mol Med (Berl). 2021 Jun;99(6):845-858. IF=4.599.

8. Yulu Zhou, Jingjing Yang, Cong Chen, Zhaoqing Li, Yongxia Chen, Xun Zhang, Linbo Wang, Jichun Zhou. Polyphyllin Ⅲ-Induced Ferroptosis in MDA-MB-231 Triple-Negative Breast Cancer Cells can Be Protected Against by KLF4-Mediated Upregulation of xCT. Front Pharmacol. 2021 May 10;12:670224. IF=5.810.

9. Qinchuan Wang, Xiyong Liu, Chen Chen, Jida Chen, Beisi Xu, Lini Chen, Jichun Zhou, Yasheng Huang, Wenjun Chen, Rongyue Teng, Wenhe Zhao, Lidan Jin, Jun Shen, Jianguo Shen, Yun Yen, Linbo Wang. A predictive signature for oxaliplatin and 5-fluorouracil based chemotherapy in locally advanced gastric cancer. Transl Oncol. 2021 Jan;14(1):100901. IF=4.243.

10. Li Z, Chen L, Chen C, Zhou Y, Hu D, Yang J, Chen Y, Zhuo W, Mao M, Zhang X, Xu L, Wang L, Zhou J. Targeting ferroptosis in breast cancer. Biomark Res 2020 Nov 05;81(1). IF=6.148.

11. Xiong H, Shen J, Chen Z, Yang J, Xie B, Jia Y, Jayasinghe U, Wang J, Zhao W, Xie S, Wang L, Zhou J. H19/let-7/Lin28 ceRNA network mediates autophagy inhibiting epithelial-mesenchymal transition in breast cancer. Int J Oncol. 2020 Mar;56(3):794-806. IF=5.650.

12. Zhou Y, Shen Y, Chen C, Sui X, Yang J, Wang L, Zhou J. The crosstalk between autophagy and ferroptosis: what can we learn to target drug resistance in cancer? Cancer Biol Med. 2019 Nov;16(4):630-646. IF=5.432.

13. Mao M, Chen Y, Jia Y, Yang J, Wei Q, Li Z, Chen L, Chen C, Wang L. PLCA8 suppresses breast cancer apoptosis by activating the PI3k/AKT/NF‐κB pathway. J Cell Mol Med. 2019;23:6930–6941. IF=4.658.

14. Wang J, Xie S, Yang J, Xiong H, Jia Y, Zhou Y, Chen Y, Ying X, Chen C, Ye C, Wang L, Zhou J. The long noncoding RNA H19 promotes tamoxifen resistance in breast cancer via autophagy. J Hematol Oncol 2019 Jul 24;12(1). IF=11.059.

15. Dong M, Luo L, Ying X, Lu X, Shen J, Jiang Z, Wang L. Comparable efficacy and less toxicity of pegylated liposomal doxorubicin versus epirubicin for neoadjuvant chemotherapy of breast cancer: a case-control study. Onco Targets Ther. 2018 Jul 23;11:4247-4252. IF=3.337.

16. Xie L, Li X, Wang Q, Zhou J, Shen J, Luo L, Lu Y, Wang L. Effects of core needle biopsy and subsequent neoadjuvant chemotherapy on molecular alterations and outcome in breast cancer. Onco Targets Ther. 2018 Feb 1;11:677-685. IF=3.337.

17. Jia Y, Ying X, Zhou J, Chen Y, Luo X, Xie S, Wang QC, Hu W, Wang L. The novel KLF4/PLAC8 signaling pathway regulates lung cancer growth. Cell Death Dis. 2018 May 22;9(6):603. IF=6.304.

 

先后指导博士研究生23人，其中在读10人；硕士研究生49人，其中在读4人。