黄玉美，1993年9月，肿瘤学博士，浙江省人民医院肿瘤内科主治医师

 

(1) 2015-09至2020-06, 华中科技大学, 肿瘤学, 博士

(2) 2010-09至2015-06, 华中科技大学, 临床医学, 学士

 

(1) 2024-12 至今, 杭州医学院, 附属人民医院（浙江省人民医院）肿瘤内科, 主治医师

(2) 2020-08 至2024-11, 杭州医学院, 附属人民医院（浙江省人民医院）肿瘤内科, 住院医师

 

浙江省抗癌协会临床研究专委会青年委员

 

(1) 国家自然科学青年基金, USP28介导的FOXK1去泛素化激活Hippo信号调控肺癌放疗敏感性的研究, 2022-01至2024-12, 资助期满, 主持

(2) 浙江省自然科学青年基金, 蛋白激酶RSK2调控UBE2O蛋白降解在肝癌侵袭转移中的作用与分子机制研究, 2022-01至2024-12, 资助期满, 主持

(3) 浙江省医药卫生科技厅项目, USP11介导的CDK10去泛素化调控JNK/c-JUN信号通路抑制肺癌肿瘤形成与放疗抵抗的作用与机制研究，2025-01至2027-12, 在研, 主持

 

(1)Yumei Huang#, Kaishun Hu#, Sheng Zhang#, Xiaorong Dong, Zhongyuan Yin, Rui Meng, Yingchao Zhao, Xiaofang Dai, Tao Zhang, Kunyu Yang, Li Liu, Kai Huang, Shaojun Shi, Yu Zhang, Junjie Chen, Gang Wu*, Shuangbing Xu*, S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer, Theranostics, 2018, 8(5): 1286-1300. (IF：12.4)

(2)Yumei Huang#, Xijie Yang#, Yanwei Lu, Ye Zhao, Rui Meng, Sheng Zhang, Xiaorong Dong, Shuangbing Xu*, Gang Wu*, UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance, Cell Death & Differentiation, 2021, 28(2): 671-684. (IF：13.7)

(3)Yimei Meng#, Chaojin Hong, Sifu Yang, Zhiquan Qin, Liu Yang* and Yumei Huang*, Roles of USP9X in cellular functions and tumorigenesis, Oncology Letters, 2023, 26(6): 506. (IF：2.9)

(4)Jianming Tang#*, Jing Li#, Jiayan Lian#, Yumei Huang#, Yaqing Zhang#, Yanwei Lu, Guansheng Zhong, Yaqi Wang, Zhitao Zhang, Xin Bai, Min Fang, Luming Wu, Haofei Shen, Jingyuan Wu, Yiqing Wang*, Lei Zhang*, Haibo Zhang*, CDK2-activated TRIM32 phosphorylation and nuclear translocation promotes radioresistance in triple-negative breast cancer, Journal of Advanced Research, 2023, 19:S2090-1232(23)00260-6. (IF：11.4)

(5)Chaojin Hong#, Yimei Meng, Anchen Qiu, Haibo Zhang, Liu Yang, Yupeng Hong* and Yumei Huang*, Downregulated CDK10 promotes cancer progression and radioresistance in lung cancer through activating the JNK/c-Jun signaling pathway, BMB Reports, 2024,57(7):336-341.(IF：2.9)

(6)Yumei Huang#*, Anchen Qiu#, Yimei Meng#, Ming Lin#, Yunhong Xu*, Liu Yang*, RSK2-mediated phosphorylation and degradation of UBE2O inhibits hepatocellular carcinoma growth and resistance to radiotherapy, Cancer Letters, 2025, 615: 217558. （IF：9.1）

(7)Yimei Meng#, Yunhong Xu#, Anchen Qiu#, Ming Lin#, Liu Yang*, Yumei Huang*, USP28-mediated deubiquitination of FOXK1 activates the Hippo signaling pathway to regulate cell proliferation and radiosensitivity in lung cancer, Life Sciences, 2025, 366-367: 123483. （IF：5.2）