主任医师，医学博士，浙江省人民医院临床心理科副主任，杭州医学院精神病学教研室副教授。浙江省人民医院国家级住培基地（精神病学专业）基地教学主任。

 

1998.09--2003.07  本科 济宁医学院 临床医学专业 

2003.09--2006.07  硕士 浙江大学医学院 精神病与精神卫生学 

2019.04--2022.03  博士 日本国千叶大学医学药学府先端医学药学专攻 

 

200607-200904 浙江省台州医院

200905-至今       浙江省人民医院
（2025年1月-12月，作为中组部团中央第25批博士服务团成员，在甘肃省第二人民医院挂职副院长）

 

中国老年保健医学研究会认知与心理疾病分会常务委员兼秘书，

中国老年保健协会阿尔茨海默病分会 委员，

浙江省医师协会精神科医师分会 委员，

浙江省预防医学会精神医学分会 委员，

浙江省医学会行为医学分会 副主任委员，

浙江省医学会心身医学分会 委员，

浙江省康复医学会睡眠障碍专委会 常务委员，

浙江省中西医结合学会精神疾病专委会 委员，

浙江省数理医学会心境障碍与人工智能诊治专委会 委员。

 

1.谭云飞 SIRT1-p53、cAMP/CREB信号通路参与慢性低氧加重阿尔茨海默

动物模型记忆与认知功能减退的分子机制研究   浙江省医药卫生科技计划 2018278601

2.谭云飞 应用心肺呼吸耦合技术分析和评估阿尔茨海默病患者睡眠紊乱的现

况与疗效   浙江省医药卫生科技计划面上项目  2019339010

3.谭云飞 R-氯胺酮调控BDNF/TrkB通路改善慢性社会挫败应激模型小鼠记忆损

伤及海马胶质细胞激活 浙江省基础公益研究计划项目 LY20H090021

 

1: Tan Y, Fang L, Zhu Y, Hashimoto K. Reply to "Letter to the Editor: Hearing

loss and depression - Comprehensive community support". J Psychiatr Res. 2025

Jan;181:348-349. doi: 10.1016/j.jpsychires.2024.11.036. Epub 2024 Nov 28. PMID:

39642473.

2: Tan Y, Hashimoto K. Therapeutic potential of ketamine in management of

epilepsy: Clinical implications and mechanistic insights. Asian J Psychiatr.

2024 Nov;101:104246. doi: 10.1016/j.ajp.2024.104246. Epub 2024 Sep 19. PMID:

39366036.

3: Tan Y, Fang L, Zhu Y, Hashimoto K. Relationship between hearing loss and

depression: A cross-sectional analysis from the National Health and Nutrition

Examination Survey 2015-2018. J Psychiatr Res. 2024 Oct;178:1-7. doi:

10.1016/j.jpsychires.2024.07.038. Epub 2024 Jul 30. PMID: 39096760.

4: Tan Y, Zhu J, Hashimoto K. Autophagy-related gene model as a novel risk

factor for schizophrenia. Transl Psychiatry. 2024 Feb 13;14(1):94. doi:

10.1038/s41398-024-02767-5. PMID: 38351068; PMCID: PMC10864401.

5: Wang X, Chang L, Wan X, Tan Y, Qu Y, Shan J, Yang Y, Ma L, Hashimoto K.

Corrigendum to "(R)-ketamine ameliorates demyelination and facilitates

remyelination in cuprizone-treated mice: A role of gut-microbiota-brain axis"

[Neurobiol Dis. 165 (2022):105635.]. Neurobiol Dis. 2022 Aug;170:105779. doi:

10.1016/j.nbd.2022.105779. Epub 2022 May 27. PMID: 35644311.

6: Wang X, Chang L, Wan X, Tan Y, Qu Y, Shan J, Yang Y, Ma L, Hashimoto K.

(R)-ketamine ameliorates demyelination and facilitates remyelination in

cuprizone-treated mice: A role of gut-microbiota-brain axis. Neurobiol Dis. 2022

Apr;165:105635. doi: 10.1016/j.nbd.2022.105635. Epub 2022 Jan 25. PMID:

35085752.

7: Tan Y, Fujita Y, Pu Y, Chang L, Qu Y, Wang X, Hashimoto K. Repeated

intermittent administration of (R)-ketamine during juvenile and adolescent

stages prevents schizophrenia-relevant phenotypes in adult offspring after

maternal immune activation: a role of TrkB signaling. Eur Arch Psychiatry Clin

Neurosci. 2022 Jun;272(4):693-701. doi: 10.1007/s00406-021-01365-6. Epub 2022

Jan 3. PMID: 34977960; PMCID: PMC9095544.

8: Wang X, Chang L, Tan Y, Qu Y, Shan J, Hashimoto K. (R)-ketamine ameliorates

the progression of experimental autoimmune encephalomyelitis in mice. Brain Res

Bull. 2021 Dec;177:316-323. doi: 10.1016/j.brainresbull.2021.10.013. Epub 2021

Oct 22. PMID: 34688833.

9: Wang S, Ishima T, Qu Y, Shan J, Chang L, Wei Y, Zhang J, Pu Y, Fujita Y, Tan

Y, Wang X, Ma L, Wan X, Hammock BD, Hashimoto K. Ingestion of Faecalibaculum

rodentium causes depression-like phenotypes in resilient Ephx2 knock-out mice: A

role of brain-gut-microbiota axis via the subdiaphragmatic vagus nerve. J Affect

Disord. 2021 Sep 1;292:565-573. doi: 10.1016/j.jad.2021.06.006. Epub 2021 Jun

11. PMID: 34147969; PMCID: PMC8282729.

10: Pu Y, Tan Y, Qu Y, Chang L, Wang S, Wei Y, Wang X, Hashimoto K. A role of

the subdiaphragmatic vagus nerve in depression-like phenotypes in mice after

fecal microbiota transplantation from Chrna7 knock-out mice with depression-like

phenotypes. Brain Behav Immun. 2021 May;94:318-326. doi:

10.1016/j.bbi.2020.12.032. Epub 2021 Jan 8. PMID: 33422641.

11: Qu Y, Shan J, Wang S, Chang L, Pu Y, Wang X, Tan Y, Yamamoto M, Hashimoto K.

Rapid-acting and long-lasting antidepressant-like action of (R)-ketamine in Nrf2

knock-out mice: a role of TrkB signaling. Eur Arch Psychiatry Clin Neurosci.

2021 Apr;271(3):439-446. doi: 10.1007/s00406-020-01208-w. Epub 2020 Nov 12.

PMID: 33180200.

12: Wang S, Ishima T, Zhang J, Qu Y, Chang L, Pu Y, Fujita Y, Tan Y, Wang X,

Hashimoto K. Ingestion of Lactobacillus intestinalis and Lactobacillus reuteri

causes depression- and anhedonia-like phenotypes in antibiotic-treated mice via

the vagus nerve. J Neuroinflammation. 2020 Aug 15;17(1):241. doi:

10.1186/s12974-020-01916-z. PMID: 32799901; PMCID: PMC7429467.

13: Pu Y, Yang J, Chang L, Qu Y, Wang S, Zhang K, Xiong Z, Zhang J, Tan Y, Wang

X, Fujita Y, Ishima T, Wang D, Hwang SH, Hammock BD, Hashimoto K. Maternal

glyphosate exposure causes autism-like behaviors in offspring through increased

expression of soluble epoxide hydrolase. Proc Natl Acad Sci U S A. 2020 May

26;117(21):11753-11759. doi: 10.1073/pnas.1922287117. Epub 2020 May 12. Erratum

in: Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2100100118. doi:

10.1073/pnas.2100100118. PMID: 32398374; PMCID: PMC7260984.

14: Pu Y, Chang L, Qu Y, Wang S, Tan Y, Wang X, Zhang J, Hashimoto K. Glyphosate

exposure exacerbates the dopaminergic neurotoxicity in the mouse brain after

repeated administration of MPTP. Neurosci Lett. 2020 Jun 21;730:135032. doi:

10.1016/j.neulet.2020.135032. Epub 2020 May 7. PMID: 32387710.

15: Qu Y, Zhang K, Pu Y, Chang L, Wang S, Tan Y, Wang X, Zhang J, Ohnishi T,

Yoshikawa T, Hashimoto K. Betaine supplementation is associated with the

resilience in mice after chronic social defeat stress: a role of brain-gut-

microbiota axis. J Affect Disord. 2020 Jul 1;272:66-76. doi:

10.1016/j.jad.2020.03.095. Epub 2020 Apr 29. PMID: 32379622.

16: Tan Y, Hashimoto K. Risk of psychosis after repeated intermittent

administration of (S)-ketamine, but not (R)-ketamine, in mice. J Affect Disord.

2020 May 15;269:198-200. doi: 10.1016/j.jad.2020.03.040. Epub 2020 Apr 2. PMID:

32339136.

17: Zhang J, Tan Y, Chang L, Hammock BD, Hashimoto K. Increased expression of

soluble epoxide hydrolase in the brain and liver from patients with major

psychiatric disorders: A role of brain - liver axis. J Affect Disord. 2020 Jun

1;270:131-134. doi: 10.1016/j.jad.2020.03.070. Epub 2020 Apr 8. PMID: 32339103;

PMCID: PMC7243919.

18: Zhang K, Yang C, Chang L, Sakamoto A, Suzuki T, Fujita Y, Qu Y, Wang S, Pu

Y, Tan Y, Wang X, Ishima T, Shirayama Y, Hatano M, Tanaka KF, Hashimoto K.

Essential role of microglial transforming growth factor-β1 in antidepressant

actions of (R)-ketamine and the novel antidepressant TGF-β1. Transl Psychiatry.

2020 Jan 27;10(1):32. doi: 10.1038/s41398-020-0733-x. PMID: 32066676; PMCID:

PMC7026089.

19: Zhang K, Sakamoto A, Chang L, Qu Y, Wang S, Pu Y, Tan Y, Wang X, Fujita Y,

Ishima T, Hatano M, Hashimoto K. Splenic NKG2D confers resilience versus

susceptibility in mice after chronic social defeat stress: beneficial effects of

(R)-ketamine. Eur Arch Psychiatry Clin Neurosci. 2021 Apr;271(3):447-456. doi:

10.1007/s00406-019-01092-z. Epub 2019 Dec 24. PMID: 31875248; PMCID: PMC7981328.

20: Tan Y, Fujita Y, Qu Y, Chang L, Pu Y, Wang S, Wang X, Hashimoto K.

Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent

repeated intermittent administration of (R)-ketamine, but not (S)-ketamine: Role

of BDNF-TrkB signaling. Pharmacol Biochem Behav. 2020 Jan;188:172839. doi:

10.1016/j.pbb.2019.172839. Epub 2019 Dec 19. PMID: 31866390.

21: Ohnishi T, Balan S, Toyoshima M, Maekawa M, Ohba H, Watanabe A, Iwayama Y,

Fujita Y, Tan Y, Hisano Y, Shimamoto-Mitsuyama C, Nozaki Y, Esaki K, Nagaoka A,

Matsumoto J, Hino M, Mataga N, Hayashi-Takagi A, Hashimoto K, Kunii Y, Kakita A,

Yabe H, Yoshikawa T. Investigation of betaine as a novel psychotherapeutic for

schizophrenia. EBioMedicine. 2019 Jul;45:432-446. doi:

10.1016/j.ebiom.2019.05.062. Epub 2019 Jun 26. PMID: 31255657; PMCID:

PMC6642071.

 

1、方丽丽（2023级）

2、朱怡晨（2023级）

3、刘垚（2024级）