浙江大学医学院附属邵逸夫医院特聘研究员，兼任绍兴文理学院副教授 ，CELL DEATH & DISEASE 审稿人，NANO LETTERS 审稿人，BRITISH JOURNAL OF PHARMACOLOGY审稿人，国际华人骨研学会终生会员，中国药学会高级会员，中华中医药学会普通会员

 

(1) 2012-09 至 2017-06, 浙江大学, 生物化学与分子生物学, 博士

(2) 2008-09 至 2012-06, 浙江大学, 应用生物科学, 学士

 

(1) 2020-04 至今，浙江大学, 医学院附属邵逸夫医院生物医学研究中心, 研究员

(2) 2017-08 至 2020-04, 浙江大学, 医学院附属邵逸夫医院生物医学研究中心, 助理研究员

(3) 2021-11 至今, 绍兴文理学院，兼职副教授

 

2019 年浙江省骨科“青年研究奖”二等奖

2022 年浙江省自然科学奖二等奖 

miR-130a反义核酸及其衍生物在Hippo-YAP信号通路抑制剂中的应用，中国国家发明专利，CN105903036B, 公开日：2019年12月

BIT's 17th Annual Congress of International Drug Discovery Science and Technology-2019 大会报告 

5th International Conference on Orthopedics, Osteoporosis and Rheumatology-2021 大会报告

 

绍兴文理学院兼职教授

CELL DEATH & DISEASE 审稿人

NANO LETTERS 审稿人

BRITISH JOURNAL OF PHARMACOLOGY审稿人

国际华人骨研学会终生会员

中国药学会高级会员

中华中医药学会普通会员

 

(1) 国家自然科学基金委员会, 面上项目, 82072960, CircVRK1 调控的代谢重编程在骨肉瘤发生发展中的 作用机制研究, 2021-01-01 至 2024-12-31, 55 万元, 在研, 主持

(2) 国家自然科学基金委员会, 面上项目, 82272522，LncRNA CADM1-AS 介导软骨细胞生理条件下 NOS2 非经典抑制途径功能机制研究与骨关节炎治疗, 2023-01-01 至 2026-12-31, 52 万元,在研，主持

(3) 国家自然科学基金委员会, 青年科学基金项目, 81802680, Hsa_circ_0001461 促进骨肉瘤侵袭转移的 分子机制研究 , 2019-01-01 至 2021-12-31, 23 万元, 结题, 主持

(4) 浙江省自然科学基金委员会, 杰出青年项目, LR22H060001, 蛋白琥珀酰化修饰在软骨细胞衰老中的功 能和机制研究, 2022-01 至 2024-12, 80 万元, 在研, 主持

(5) 浙江省卫健委, 医药卫生创新项目创新人才支持计划, 2020384891, CircFNDC3B 抑制关节炎进展的 分子机制研究, 2020-01 至 2022-12, 3 万元, 结题, 主持

 

1.Shen, SY#; Wu, YZ#; Chen, JX#; Xie, Z; Huang, KM; Wang, GL; Yang, YT; Ni, WY; Chen, ZJ; Shi, PH; Ma, Y*马彦; Fan, SW*范顺武,CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETSrelated gene, ANNALS OF THE RHEUMATIC DISEASES.2019 Jun;78(6):826-836.IF=28.003 

2.Shuying Shen#, Xiaocan Guo#, Huan Yan, Yi Lu, Xinyan Ji, Li Li, Tingbo Liang, Dawang Zhou6, Xin-Hua  Feng, Jonathan C Zhao, Jindan Yu, Xing-Guo Gong, Lei Zhang, Bin Zhao*,A miR-130a-YAP positive feedback  loop promotes organ size and tumorigenesis,CELL RESEARCH. 2015 Sep;25(9):997-1012. IF=46.36

3.Shen, SY#; Yang, YT#; Shen, PY#; Ma, J; Fang, B; Wang, QX; Wang, KF; Shi, PH; Fan, SW*范顺武; Fang,  XQ* 方向前 , circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a  scaffold for RIC8A and MID1, ANNALS OF THE RHEUMATIC DISEASES.2021 Sep;80(9):1209-1219. IF=28.003 

4.Wu, YZ#; Hong, ZH#; Xu, WB#; Chen, JX; Wang, QX; Chen, JX; Ni, WY; Mei, ZX; Xie, Z; Ma, Y; Wang, JY;  Lu, JH; Chen, C; Fan, SW* 范 顺 武 ; Shen, SY* 沈 舒 滢 , Circular RNA circPDE4D Protects against  Osteoarthritis by Binding to miR-103a-3p and Regulating FGF18, MOLECULAR THERAPY.2021 Jan 6;29(1):308- 323.IF=12.910 

5.Wang J#, Xia D#, Lin Y#, Xu W#, Wu Y, Chen J, Chu J, Shen P, Weng S, Wang X*王向阳, Shen L*沈立峰,  Fan S*范顺武, Shen S*沈舒滢. Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated  anti-senescence in intervertebral disc degeneration. Exp Mol Med. 2022 Mar;54(3):285-297. IF=12.172

6.Shen, SY#; Yao, T#; Xu, YN; Zhang, DG; Fan, SW*范顺武; Ma, JJ*马建军, CircECE1 activates energy  metabolism in osteosarcoma by stabilizing c-Myc, MOLECULAR CANCER.2020 Oct 26;19(1):151.IF=41.443

7.Liu, G#; Huang, KM#; Jie, ZW#; Wu, YZ; Chen, JX; Chen, ZZ; Fang, XQ*方向前; Shen, SY*沈舒滢, CircFAT1  sponges miR-375 to promote the expression of Yes-associated protein 1 in osteosarcoma cells, MOLECULAR  CANCER.2018 Dec 4;17(1):170.IF=41.443

8.Huang, KM#; Chen, YY; Zhang, R; Wu, YZ; Ma, Y; Fang, XQ*方向前; Shen, SY*沈舒滢, Honokiol induces  apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and  in vivo, CELL DEATH & DISEASE. 2018 Feb 6;9(2):157.IF=9.696

9.Shen, SY#; Huang, KM; Wu, YZ; Ma, Y; Wang, JY; Qin, FW; Ma, JJ* 马建 军 , A miR-135b-TAZ positive  feedback loop promotes epithelial-mesenchymal transition (EMT) and tumorigenesis in osteosarcoma,  CANCER LETTERS.2017 Oct 28;407:32-44.IF=9.756 

10.Wang G#, Chen S#, Xie Z#, Shen S#, Xu W, Chen W, Li X, Wu Y, Li L, Liu B, Ding X, Qin A*秦安, Fan S* 范顺武. TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14  ubiquitination. Ann Rheum Dis. 2020 Aug;79(8):1111-1120.IF=28.003 

11. Xie Z#, Hou L#, Shen S#, Wu Y, Wang J, Jie Z, Zhao X, Li X, Zhang X, Chen J, Xu W, Ning L, Ma Q,  Wang S, Wang H, Yuan P, Fang X* 方 向 前 , Qin A* 秦 安 , Fan S* 范 顺 武 . Mechanical force promotes  dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric  dimethylarginine to enhance bone formation. Nat Commun. 2022 Jan 10;13(1):50. IF=17.693

12.Chen, JX#; Liu, G#; Wu, YZ#; Ma, JJ#; Wu, HF; Xie, Z; Chen, S; Yang, YT; Wang, SY; Shen, PY; Fang,  YF; Fan, SW; Shen, SY* 沈 舒 滢 ; Fang, XQ* 方 向 前 , CircMYO10 promotes osteosarcoma progression by  regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of beta-catenin/LEF1 complex  via effects on chromatin remodeling, MOLECULAR CANCER.2019 Oct 29;18(1):150. IF=41.443

13.Wu, YZ#; Xie, Z#; Chen, JX#; Chen, JX; Ni, WY; Ma, Y; Huang, KM; Wang, GL; Wang, JY; Ma, JJ; Shen,  SY*沈舒滢; Fan, SW*范顺武, Circular RNA circTADA2A promotes osteosarcoma progression and metastasis by  sponging miR-203a-3p and regulating CREB3 expression, MOLECULAR CANCER.2019 Apr 2;18(1):73. IF=41.443 

14.Yang, YT#; Shen, PY#; Yao, T#; Ma, J; Chen, ZZ; Zhu, JJ; Gong, Z; Shen, SY*沈舒滢; Fang, XQ*方向前,  Novel role of circRSU1 in the progression of osteoarthritis by adjusting oxidative stress,  THERANOSTICS.2021 Jan 1;11(4):1877-1900.IF=11.600 

15.Shen, PY#; Yang, YT#; Liu, G#; Chen, WJ; Chen, JX; Wang, QX; Gao, HL; Fan, SW*范顺武; Shen, SY*沈舒 滢; Zhao, X*赵兴, CircCDK14 protects against Osteoarthritis by sponging miR-125a-5p and promoting the  expression of Smad2, THERANOSTICS.2020 Jul 11;10(20):9113-9131.IF=11.600 

16.Gong Z#, Wang K#, Chen J#, Zhu J, Feng Z, Song C, Zhang Z, Wang H, Fan S*范顺武, Shen S*沈舒滢, Fang  X*方向前,CircZSWIM6 mediates dysregulation of ECM and energy homeostasis in ageing chondrocytes through  RPS14 post-translational modification. Clin Transl Med. 2023 Jan;13(1):e1158. IF=8.554 

17.Ma, Y#; Wu, YZ#; Chen, JX#; Huang, KM; Ji, B; Chen, ZJ; Wang, Q; Ma, JJ*ma 马建军; Shen, SY*沈舒滢;  Zhang, JF* 张建锋 , miR-10a-5p Promotes Chondrocyte Apoptosis in Osteoarthritis by Targeting HOXA1,  MOLECULAR THERAPY NUCLEIC ACIDS.2019 Mar 1;14:398-409.IF=10.183 

18.Ni, WY#; Jiang, C#; Wu, YZ#; Zhang, HT#; Wang, LL; Yik, JHN; Haudenschild, DR; Fan, SW*范顺武; Shen,  SY*沈舒滢; Hu, Z*胡子昂, CircSLC7A2 protects against osteoarthritis through inhibition of the miR- 4498/TIMP3 axis, CELL PROLIFERATION.2021 Jun;54(6):e13047. IF==8.755 

19.Xu, YI#; Yao, T#; Ni, HN#; Zheng, RJ; Huang, KM; Huang, YZ; Gao, J; Qiao, D; Shen, SY*沈舒滢; Ma,  JJ* 马 建 军 , Circular RNA circSIPA1L1 Contributes to Osteosarcoma Progression Through the miR-411- 5p/RAB9A Signaling Pathway, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021 Apr 22;9:642605.IF=6.0814

 

本科生课程：《医学英语》2学时；《留学生医学汉语》4学时；

联合培养博士生2名、单独指导硕士生2名