张岩，教育部长江学者，浙江大学求是特聘教授，长聘正教授，浙江省特聘专家，先后获得国家优青、国家青千、国自然专项、科技部重点研发计划青年项目等资助，围绕GPCR结构药理方法学、激活机制、选择性信号转导和干预等做出了系列创新成果，为重大疾病的精准治疗和探寻创新靶点提供了理论依据。已发表通讯作者或第一作者（共同）论文近50篇，包括Nature（8篇）、Science（3篇）、Cell、CellResearch（5篇）、MolecularCell（3篇）和NatureChemicalBiology等。工作受到国际同行广泛关注和好评，十余次获F1000推荐，10余篇文章入选ESI高被引论文，2篇入选ESI热门论文；工作入选2019年中国医学重大进展，2021浙江大学十大学术进展等。

 

2007年9月-2013年6月，中国科学院上海有机化学研究所、有机化学，博士；

2003年9月-2007年6月，山东师范大学、应用化学，学士。

 

2022年1月至今，浙江大学，长聘教授；

2018年1月-2022年1月，浙江大学，百人计划研究员；

2017年6月-2018年1月，斯坦福大学，博士后；

2013年11月-2017年5月，密歇根大学，博士后。

 

“求是”特聘教授、长聘教授、教育部“长江学者”、浙江大学“蛋白质机器与细胞命运调控”创新团队带头人、国家优青，国家重点研发计划首席青年科学家、浙江省特聘专家、浙江省杰青、谈家桢生命科学创新奖、树兰医学青年奖、中国医学重大进展、浙江大学十大学术进展。

 

1.中国神经科学学会离子通道与受体分会副秘书长；

2.中国病理生理学会第六届受体和信号转导专业委员会委员兼青年委员工作小组组长；

3.中国药理学会生化与分子药理学专业委员会委员；

4.中国生物物理学会青年委员会委员；

5.中国神经科学学会精神病学基础与临床分会青年委员。

 

1.  国家重点研发计划青年项目：组胺H3R精准调控神经干细胞特化的机制研究及其药物发现，470万元；

2.  国家“千人计划”青年项目：GPCR的结构与功能研究及其分子药理学，300万元；

3.  国家自然科学基金优秀青年项目：结构药理学，120万元；

4.  浙江省自然科学基金杰出青年项目：G蛋白偶联受体动态构象的调控机制及其分子药理学研究，80万元。

 

1.     Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP, Xie X, Yu X, Zhang Y. Structural basis of GPBAR activation and bile acid recognition. Nature. 2020 Nov;587(7834):499-504.

2.     Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y. Structure and dynamics of the active human parathyroid hormone receptor-1. Science. 2019 Apr 12;364(6436):148-153.

3.     Shen C, Mao C, Xu C, Jin N, Zhang H, Shen DD, Shen Q, Wang X, Hou T, Chen Z, Rondard P, Pin JP, Zhang Y, Liu J. Structural basis of GABA_B receptor-Gi protein coupling. Nature. 2021 Jun;594(7864):594-598.

4.     Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE, Zhang Y, Sun JP. Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex. Nature. 2021 Jan;589(7843):620-626.

5.     Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP. Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science. 2023 Mar 2:eadd6220.

6.     Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harps?e K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE. Structural insights into the lipid and ligand regulation of serotonin receptors. Nature. 2021 Apr;592(7854):469-473.

7.     Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE. Structures of full-length glycoprotein hormone receptor signalling complexes. Nature. 2021 Oct;598(7882):688-692.

8.     Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE. Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell. 2021 Feb 18;184(4):931-942.e18.

9.     Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, Shen DD, Dai A, Xie S, Zhou Y, Qin J, Sun JP, Scharf DH, Hou T, Zhou T, Wang MW, Zhang Y. Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res. 2021 Nov;31(11):1163-1175.

10.  Chen LN, Wang WW, Dong YJ, Shen DD, Guo J, Yu X, Qin J, Ji SY, Zhang H, Shen Q, He Q, Yang B, Zhang Y, Li Q, Mao C. Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes. Cell Res. 2022 Aug;32(8):785-788.

11.  Ji SY, Dong YJ, Chen LN, Zang SK, Wang J, Shen DD, Guo J, Qin J, Zhang H, Wang WW, Shen Q, Zhang Y, Song Z, Mao C. Molecular basis for the activation of thyrotropin-releasing hormone receptor. Cell Discov. 2022 Oct 25;8(1):116.

12.  Zhai X, Mao C, Shen Q, Zang S, Shen DD, Zhang H, Chen Z, Wang G, Zhang C, Zhang Y, Liu Z. Molecular insights into the distinct signaling duration for the peptide-induced PTH1R activation. Nat Commun. 2022 Oct 21;13(1):6276.

13.  Mao C, Shen C, Li C, Shen DD, Xu C, Zhang S, Zhou R, Shen Q, Chen LN, Jiang Z, Liu J, Zhang Y. Cryo-EM structures of inactive and active GABA_B receptor. Cell Res. 2020 Jul;30(7):564-573.

14.  Xu P, Huang S, Mao C, Krumm BE, Zhou XE, Tan Y, Huang XP, Liu Y, Shen DD, Jiang Y, Yu X, Jiang H, Melcher K, Roth BL, Cheng X, Zhang Y, Xu HE. Structures of the human dopamine D3 receptor-Gi complexes. Mol Cell. 2021 Mar 18;81(6):1147-1159.e4.

15.  Zhuang Y, Krumm B, Zhang H, Zhou XE, Wang Y, Huang XP, Liu Y, Cheng X, Jiang Y, Jiang H, Zhang C, Yi W, Roth BL, Zhang Y, Xu HE. Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor. Cell Res. 2021 May;31(5):593-596.

16.  Yin W, Mao C, Luan X, Shen DD, Shen Q, Su H, Wang X, Zhou F, Zhao W, Gao M, Chang S, Xie YC, Tian G, Jiang HW, Tao SC, Shen J, Jiang Y, Jiang H, Xu Y, Zhang S, Zhang Y, Xu HE. Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science. 2020 Jun 26;368(6498):1499-1504.

17.  Shao Z, Shen Q, Yao B, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Ma H, Chen ZH, Xu HE, Ying S, Zhang Y, Shen H. Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1. Nat Chem Biol. 2022 Mar;18(3):264-271.

18.  Ma S, Shen Q, Zhao LH, Mao C, Zhou XE, Shen DD, de Waal PW, Bi P, Li C, Jiang Y, Wang MW, Sexton PM, Wootten D, Melcher K, Zhang Y, Xu HE. Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors. Mol Cell. 2020 Feb 6;77(3):669-680.e4.

19.  Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harps?e K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE. GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol Cell. 2022 Jul 21;82(14):2681-2695.e6.

20.  Qin J, Cai Y, Xu Z, Ming Q, Ji SY, Wu C, Zhang H, Mao C, Shen DD, Hirata K, Ma Y, Yan W, Zhang Y, Shao Z. Molecular mechanism of agonism and inverse agonism in ghrelin receptor. Nat Commun. 2022 Jan 13;13(1):300.

21.  Zhou F, Zhang H, Cong Z, Zhao LH, Zhou Q, Mao C, Cheng X, Shen DD, Cai X, Ma C, Wang Y, Dai A, Zhou Y, Sun W, Zhao F, Zhao S, Jiang H, Jiang Y, Yang D, Eric Xu H, Zhang Y, Wang MW. Structural basis for activation of the growth hormone-releasing hormone receptor. Nat Commun. 2020 Oct 15;11(1):5205.

22.  Duan J, Shen DD, Zhou XE, Bi P, Liu QF, Tan YX, Zhuang YW, Zhang HB, Xu PY, Huang SJ, Ma SS, He XH, Melcher K, Zhang Y, Xu HE, Jiang Y. Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy. Nat Commun. 2020 Aug 17;11(1):4121.

23.  Duan J, Shen DD, Zhao T, Guo S, He X, Yin W, Xu P, Ji Y, Chen LN, Liu J, Zhang H, Liu Q, Shi Y, Cheng X, Jiang H, Eric Xu H, Zhang Y, Xie X, Jiang Y. Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors. Nat Commun. 2022 Mar 15;13(1):1364.

24.  Zhao LH, Lin J, Ji SY, Zhou XE, Mao C, Shen DD, He X, Xiao P, Sun J, Melcher K, Zhang Y, Yu X, Xu HE. Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor. Nat Commun. 2022 Nov 5;13(1):6670.

25.  Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW. Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor. Nat Commun. 2021 Jun 18;12(1):3763.

26.  Sun W, Chen LN, Zhou Q, Zhao LH, Yang D, Zhang H, Cong Z, Shen DD, Zhao F, Zhou F, Cai X, Chen Y, Zhou Y, Gadgaard S, van der Velden WJC, Zhao S, Jiang Y, Rosenkilde MM, Xu HE, Zhang Y, Wang MW. A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor. Cell Res. 2020 Dec;30(12):1098-1108.

27.  Qu C, Mao C, Xiao P, Shen Q, Zhong YN, Yang F, Shen DD, Tao X, Zhang H, Yan X, Zhao RJ, He J, Guan Y, Zhang C, Hou G, Zhang PJ, Hou G, Li Z, Yu X, Chai RJ, Guan YF, Sun JP, Zhang Y. Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E2 receptor EP2 subtype. Sci Adv. 2021 Apr 2;7(14):eabf1268.

28.  Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM. Structural insights into human brain-gut peptide cholecystokinin receptors. Cell Discov. 2022 Jun 7;8(1):55.

 

培养博士研究生10名，硕士研究生2名。