浙江省中医药研究院（浙江省立同德医院,浙江省精神卫生中心），中西医结合肿瘤研究所，浙江省中西医结合肿瘤防治技术重点实验室，副研究员，副所长

 

2009.09-2012.09，浙江大学，博士

2007.09-2009.06，浙江大学，硕士

2003.09-2007.06，青岛农业大学，学士

 

202401-至今，浙江中医药研究院，浙江省立同德医院，中西医结合肿瘤研究所，研究员

201501-202312，浙江省中医药研究院，浙江省立同德医院，中西医结合肿瘤研究所，副研究员

201709-201809，中国中医科学院中药研究所，访问学者

201505-201601，美国耶鲁大学，药理系郑永齐教授实验室，访问学者

201210-201412，浙江大学，预防兽医学博士后，助理研究员

 

中华中医药学会精准医疗分会委员

 

浙江省医药卫生科技计划项目，肺/EGFR双靶向多肽脂质纳米颗粒调控EREG/EGFR旁通路在缓解EGFR-TKI耐药治疗中的作用及机制，2023/01-2025/12，5万元，在研，主持。

浙江省立同德医院111人才项目（第二层次），2022/01-2024/12，24万元

国家自然基金面上项目，82074093，VitminD/VDR调控染色质空间构象抗乙肝纤维化及其黄芪总黄酮干预的分子机制研究，2021/01-2024/12，55万元，在研，主持

浙江省自然基金项目，LY19H280035，基于家蚕生物转化研究桑叶性寒到蚕沙性温寒热药性转化的分子机制，2019/01-2021/12，9万元，在研，主持

浙江省科技计划项目，2017F10024，基于基因突变的中医“辨证论治”非小细胞肺癌诊断平台建设，2017/01-2020/03，130万元，结题，主持

浙江省中医药研究院111人才项目，2017/01-2019/12， 10万元

国家自然科学基金面上项目，81673809，基于TAMs-PI3K的抑肺饮早期干预肿瘤微环境抑制肺癌转移的机制研究，2017/01-2020/12，直接经费：62万元，结题，参加

浙江省中医药科技计划青年人才项目，2016ZQ002，基于LC-MS及细胞信号通路分析不同商品批次大黄谱效关系及商品规格等级划分，2016/01-2018/12，3万元，在研，主持

国家自然科学基金青年项目，31302033，家蚕微孢子虫与BmN细胞线粒体之间的相互作用机制研究，2014/01-2016/12，23万，结题，主持

中国博士后基金面上二等资助，2013M531471，传染性软化病病毒基因组5′端RNA与家蚕蛋白的相互作用，2013/01-2014/12，5万，结题，主持

国家自然科学基金面上项目，31172262，家蚕传染性软化病病毒翻译机制及侵染机制的研究，2012/01-2015/12，60万，结题，参加

 

1. 第一作者或通讯作者论文

1)        Jiacheng Li, Xiaozhen Liu, Lin Chen, Xinping Zhu, Zhihong Yu, Liyao Dong, Xinyun Zhao, Hongling Zou, Qin Wei, Yongcai Feng, Yongqiang Zhu, Kequn Chai, Qun Li, Mingqian Li. Isopimaric acid, an ion channel regulator, regulates calcium and oxidative phosphorylation pathways to inhibit breast cancer proliferation and metastasis. Toxicol Appl Pharmacol. 2023 Feb 6;462:116415.doi: 10.1016/j.taap.2023.116415.

2)        Lin Chen , Qihong Jiang, Hongling Lu, Chenkai Jiang, Wenjun Hu, Shaofang Yu, Xingwei Xiang, Chin Ping Tan, Yongcai Feng, Jianfang Zhang, Mingqian Li*, Guoxin Shen*. Antidiabetic effect of sciadonic acid on type 2 diabetic mice through activating the PI3K-AKT signaling pathway and altering intestinal flora. Front Nutr. 2022 Dec 23;9:1053348. doi: 10.3389/fnut.2022.1053348.

3)        Mingqian Li, Fei Li, Jiabin Chen, He Su, Guanping Chen, Jili Cao, Jiacheng Li, Liyao Dong, Zhihong Yu, Yifan Wang, Chun Zhou, Yongqiang Zhu, Qin Wei, Qun Li, Kequn Chai. Mechanistic insights on cytotoxicity of KOLR, Cinnamomum pauciflorum Nees leaf derived active ingredient, by targeting signaling complexes of phosphodiesterase 3B and rap guanine nucleotide exchange factor 3. Phytotherapy research. 2022, 36:3540–3554. doi: 10.1002/ptr.7521.

4)        Mingqian Li, Lin Chen, Yuntao Dai, Jiacheng Li, Fei Li, Qun Li, Zhihong Yu, Kequn Chai, and Yongqiang Zhu. Differential Metabolomics and Network Pharmacology Analysis of Silkworm Biotransformation between Mulberry Leaves and Silkworm Droppings. Evidence-Based Complementary and Alternative Medicine. 2021, 8819538. doi: 10.1155/2021/8819538.

5)        Qinsong Sheng, Fei Li, Guanping Chen, Jiacheng Li, Jing Li, YiFan Wang, Yingyan Lu, Qun Li, Mingqian Li*, Kequn Chai*. Ursolic Acid Regulates Intestinal Microbiota and Inflammatory Cell Infiltration to Prevent Ulcerative Colitis. Journal of Immunology Research.2021. Volume 2021, 6679316. DOI: 10.1155/2021/6679316.

6)        Gaoyun Xiong, Xiaoxing Xie, Qingliang Wang, Yanyan Zhang, Yanping Ge , Wei Lin*, Mingqian Li*. Immune cell infiltration and related core genes expression characteristics in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps. Exp Ther Med. 2020, 20(6):180. doi: 10.3892/etm.2020.9310.

7)        Mingqian Li, Xinyi He, Han Liu, Zhangwuke Fu, Xiangkang He, Xingmeng Lu. Proteomic analysis of silkworm midgut cellular proteins interacting with the 5' end of infectious flacherie virus genomic RNA. Acta Biochimica et Biophysica Sinica，2015. 47(2): 80~90. doi: 10.1093/abbs/gmu119.

8)        Mingqian Li, Nana Man, Haihong Qiu, Shunfeng Cai, Xinyi He, Xiangkang He, Xingmeng Lu.Detection of an internal translation activity in the 5' region of Bombyx mori infectious flacherie virus. Applied Microbiology and Biotechnology，2012.8.01, 95(3): 697-705. doi: 10.1007/s00253-012-3996-1

9)        Mingqian Li, Qineng Lu, Xiaofeng Wu, Nana Man, Xiaoxue Chen, Wei Jin, Xingmeng Lu. Analysis of RNA-Dependent RNA Polymerase Sequence of Infectious Flacherie Virus Isolated in China and Its Expression in BmN Cells, Agricultural Sciences in China，2009, 8(7): 872-879. Doi:10.1016/s1671-2927(08)60290-4

10)    Mingqian Li，Chen Xiaoxue，Wu Xiaoxia，Man Nana，Jin Wei，Lu Xingmeng，Genome Analysis of the Bombyx mori Infectious Flacherie Virus Isolated in China，Agricultural Sciences in China，2010.2.01，9（2）：299-305. doi: 10.1016/S1671-2927(09)60097-3

11)    李明乾，苘娜娜，蔡顺风，陈孝学，金伟，鲁兴萌，家蚕传染性软化病病毒（桐乡株）5′端非编码区基因的克隆及序列分析，蚕业科学，2009.3.15，（01）84-89

2. 既非第一作者又非通讯作者论文

1)        Qing Zhang, Jun Ren, Fangfang Wang, Mingqian Li, Manman Pan, Hui Zhang, Fan Qu. Chinese herbal medicine alleviates the pathogenesis of polycystic ovary syndrome by improving oxidative stress and glucose metabolism via mitochondrial Sirtuin 3 signaling. Phytomedicine. 2023 Jan;109:154556. doi: 10.1016/j.phymed.2022.154556. Epub 2022 Nov 18.

 

2)        Jiang Xu^#, Shuai Guo^#, Xianmei Yin^#, Mingqian Li^#, He Su^#, Xuejiao Liao, Qiushi Li, Liang Le, Shiyu Chen, Baosheng Liao, Haoyu Hu, Juan Lei, Yingjie Zhu, Xiaohui Qiu, Lu Luo, Jun Chen, Ruiyang Cheng, Zhenzhan Chang, Han Zhang, Nicholas Chieh Wu, Yiming Guo, Dianyun Hou, Jin Pei, Jihai Gao, Yan Hua, Zhihai Huang, Shilin Chen. Genomic, transcriptomic, and epigenomic analysis of a medicinal snake, Bungarus multicinctus, to provides insights into the origin of Elapidae neurotoxins. doi.org/10.1016/j.apsb.2022.11.015

 

3)        Shasha Kong, Pengyue Li, Robert Verpoorte, Mingqian Li, Yuntao Dai. Chemical and pharmacological difference between honey-fried licorice and fried licorice. J Ethnopharmacol. 2022 Oct 18;115841. doi: 10.1016/j.jep.2022.115841.

4)        Zhe Zhou, Jiabin Chen, Mingqian Li, Liping Cao, Miao Chen, Qingqian Zhang, Zhihong Yu, Kequn Chai. Xiaotan Sanjie Decoction Inhibits Gastric Cancer Cell Proliferation, Migration, and Invasion through lncRNA-ATB and miR-200A. Biomed Res Int. 2022 Aug 25;2022:7029182. doi: 10.1155/2022/7029182.

5)        Qing Zhang, Jun Ren, Fangfang Wang, Manman Pan, Long Cui, Mingqian Li, Fan Qu. Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3. Free Radic Biol Med. 2022 Jul;187:1-16. doi: 10.1016/j.freeradbiomed.2022.05.010.

6)        Xueyuan Wang, Qishu Jiao, Chaoran Wang , Runa Jin , Yanyan Zhou, Shougang Shi, Zhengjun Huang , Mingqian Li, Xuemei Qin , Shilin Chen , Yuntao Dai. Establishment of Holistic Quality Control Methods for Nelumbinis Folium Containing Alkaloids and Flavonoids with Simple HPLC Conditions. J Chromatogr Sci. 2021 Dec 30;bmab138. doi: 10.1093/chromsci/bmab138.

7)        Can Yuan, Xiufen Sha, Miao Xiong, Wenjuan Zhong, Yu Wei, Mingqian Li , Shan Tao, Fangsheng Mou, Fang Peng, Chao Zhang.Uncovering dynamic evolution in the plastid genome of seven Ligusticum species provides insights into species discrimination and phylogenetic implications. Sci Rep. 2021, 11(1):988.doi: 10.1038/s41598-020-80225-0.

8)        Xianmei Yin, Shuai Guo, Jihai Gao, Lu Luo, Xuejiao Liao, Mingqian Li, He Su, Zhihai Huang, Jiang Xu, Jin Pei, Shilin Chen. Kinetic analysis of effects of temperature and time on the regulation of venom expression in Bungarus multicinctus. Sci Rep. 2020, 10(1):14142. doi: 10.1038/s41598-020-70565-2.

9)        Xiaoxing Xie, Gaoyun Xiong, Wenjun Chen,Hongdan Fu, Mingqian Li, Xiaoying Cui. FOXD3 inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma through regulation of the PI3K-Akt pathway Biochem Cell Biol. 2020, 98(6):653-660.doi: 10.1139/bcb-2020-0011.

10)    Yifan Wang, Ruocen Liao, Xingyu Chen, Xuhua Ying , Guanping Chen, Mingqian Li, Chenfang Dong. Twist-mediated PAR1 induction is required for breast cancer progression and metastasis by inhibiting Hippo pathway. Cell Death Dis. 2020 11(7):520.

11)    Han Liu, Mingqian Li, Shunfeng Cai, Xinyi He, Yongqi Shao, Xingmeng Lu. Ricin-B-lectin enhances microsporidia Nosema bombycis infection in BmN cells from silkworm Bombyx mori，Acta Biochimica et Biophysica Sinica, 2016, 48(11): 1050~1057.

12)    Han Liu, Mingqian Li, Xinyi He, Shunfeng Cai, Xiangkang He, Xingmeng Lu. Transcriptome sequencing and characterization of ungerminated and germinated spores of Nosema bombycis. Acta Biochimica et Biophysica Sinica, 2016, 48(3): 246~256.

13)    Zhangwuke Fu, Xiangkang He, Shunfeng Cai, Han Liu, Xinyi He, Mingqian Li, Lu Xingmeng. Quantitative PCR for detection of Nosema bombycis in single silkworm eggs and newly hatched larvae，Journal of Microbiological Methods, 2016, 120: 72~78.

14)    Xinyi He, Fu Zhangwuke, Li Mingqian, Liu Han, Man Nana, Lu Xingmeng. Nosema bombycis (Microsporidia) suppresses apoptosis in BmN cells (Bombyx mori). Acta Biochimica et Biophysica Sinica，2015, 47(9): 696~702.

 

 

协助带教博士生2名，硕士生5人