浙江大学药学院副院长、中药科学与工程学系副主任，先后在美国FDA、哈佛大学医学院从事访问研究，兼任教育部药学类教指委制药工程专业分委会委员、浙江省药学会中药与天然药物专委会副主任委员。主要从事中药药效物质及质量控制技术研究，承担国家自然科学基金、国家重点研发计划课题等国家级项目10余项，作为第一/通讯作者（含共同）在Nat Commun.、Adv. Sci.、Anal. Chem.等国内外期刊发表论文80余篇，作为主要完成人获省部级科技奖励5项，获国家优秀青年科学基金与浙江省杰出青年科学基金资助，入选国家中医药多学科交叉创新团队、浙江省151人才工程及中华中医药学会中青年创新人才。

 

01/2017-至今 浙江大学药学院教授 

05/2007-12/2016 浙江大学药学院 讲师/副教授 

03/2011-04/2011 美国 FDA 国立毒理研究中心 访问科学家 

01/2013-01/2014 美国哈佛大学医学院麻省总医院系统生物学中心，访问学者

 

国家优秀青年科学基金、浙江省杰出青年科学基金资助，入选浙江省“151”人才计划。

 

教育部药学类教指委制药工程专业分委会委员、中华中医药学会中医药信息学分会副秘书长、浙江省药学会理事及中药与天然药物专委会副主任委员

 

1.国家优秀青年科学基金，中药药效物质，2019.1-2021.12，主持；

2.国家自然科学基金 “基于靶向荧光探针的中药表观遗传调控物质发现方法研究”，2018.1-2021.12，主持；  

3.国家自然科学基金“基于网络药理学的生脉方抗缺血性心肌病药效物质基础及作用机制研究”, 2012.1—2015.12，主持；

4.“重大新药创制”科技重大专项课题，“现代中药新药发现和评价技术平台建设”，2012.1—2015.12，主持；

5.国家自然科学基金 “应用蛋白质组学与信息学技术研究黄芪丹参方的配伍机制”, 2009.01— 2011.12， 主持，已结题；

 

1. Dejin Xun, Deheng Chen, Yitian Zhou, Volker M. Lauschke, Rui Wang*, Yi Wang*. Scellseg: a style-aware cell instance segmentation tool with pre-training and contrastive fine-tuning [J]. iScience, 2022, 25(12):105506.

2. Yufei Li, Hongda Sheng, Ziwei Yan, Bin Guan, Shifa Qiang, Jing Qian*, Yi Wang*. Bilirubin stabilizes the mitochondrial membranes during NLRP3 inflammasome activation [J]. Biochemical Pharmacology, 2022, 203: 115204.

3. Bo Fan, Yingchao Wang, Zhenhao Li, Dejin Xun, Jian Dong, Xiangwei Zhao, Xiaohui Fan*, Yi Wang*. Si@Ag@PEI Substrate-based SERS Sensor for Rapid Detection of Illegally Adulterated Sulfur Dioxide in Traditional Chinese Medicine [J]. Talanta, 2022, 238:122988. 

4. Chen J, Wang Y, Wang S, Zhao X, Zhao L *, Wang Y*. Salvianolic acid B and ferulic acid synergistically promote angiogenesis in HUVECs and zebrafish via regulating VEGF signaling [J]. Journal of Ethnopharmacology, 2022, 283: 114667.

5. Lu Zhao#, Hao Liu#, Yingchao Wang, Shufang Wang, Dejin Xun, Yi Wang*, Yiyu Cheng*, Boli Zhang. Multimodal Identification by Transcriptomics and Multiscale Bioassays of Active Components in Xuanfeibaidu Formula to Suppress Macrophage-Mediated Immune Response, Engineering, 2022.

6. Shujing Zhang, Yingchao Wang, Min Yu, Ye Shang, Yanxu Chang, Hong Zhao, Yu Kang, Lu Zhao, Lei Xu, Xiaoping Zhao*, Dario Difrancesco, Mirko Baruscotti, Yi Wang*. Discovery of herbacetin as a novel SGK1 inhibitor to alleviate myocardial hypertrophy [J]. Advanced Science, 2022,9, 2101485.

7. Yunru Yu#, Jing Chen#, Xiaohui Zhang, Yingchao Wang, Shufang Wang, Lu Zhao*, Yi Wang*. Identification of anti-inflammatory compounds from Zhongjing formulae by knowledge mining and high-content screening in a zebrafish model of inflammatory bowel diseases [J]. Chinese Medicine, 2021, 16:42.

8. Xiaohui Zhang#, Yule Wang#, Kai Zhang, Hongda Sheng, Yuhan Wu, Huimin Wu, Yingchao Wang, Jianli Guan, Qingfen Meng, Huahuan Li, Zhenhao Li, Guanwei Fan*,Yi Wang*. Discovery of tetrahydropalmatine and protopine regulate the expression of dopamine receptor D2 to alleviate migraine from Yuanhu Zhitong formula [J]. Phytomedicine, 91 (2021) 153702.

9. Xuechun Chen, Dejin Xun, Ruzhang Zheng, Lu Zhao, Yuqing Lu, Jun Huang, Rui Wang*, Yi Wang*, Deep-learning-assisted assessment of DNA damage based on Foci images and its application in high-content screening of lead compounds, Analytical Chemistry, 2020,92(20):14267-14277.

10. YinchuanXu#, Shujing Zhang#, Jiabing Rong#, Yao Lin, Linlin Du, Yi Wang*, Zhaocai Zhang*. Sirt3 is a novel target to treat sepsis induced myocardial dysfunction by acetylated modulation of critical enzymes within cardiac tricarboxylic acid cycle, Pharmacological Research, 2020, 159, 104887.