汪洌，博士，浙江大学求是特聘教授，博士生导师,浙江大学实验动物中心主任。

 

1999年于浙江大学生命科学院获学士学位。2004 年于中国科学院上海生化细胞所获博士学位。

 

2004 年至2010 年在美国国立卫生院癌症研究所免疫细胞生物学研究室从事博士后研究工作，2010 年作为浙江大学引进人才正式受聘于基础医学院免疫所担任教授和博士生导师,2016年起担任浙江大学实验动物中心主任，负责运行、设计和建立包括紫金港校区、余杭医学中心、转化医学研究院等多个动物中心设施，2018年作为双聘教授兼职于浙江大学医学院附属第一医院血液学研究所。

 

获国家自然基金优青，重点项目，教育部新世纪人才计划，浙江省杰出青年基金，重点项目资助，作为课题组长，骨干参与2项国家“973”研究计划。

 

担任中国免疫学会青年工作委员会第二届委员，中国细胞生物学学会细胞结构与功能分会委员，浙江省实验动物行业协会副理事长，浙江省生物医学学会监事，浙江省免疫学会基础医学委员会委员。

 

1. 2011年浙江省自然科学基金杰出青年项目。

2. 2011年国家自然科学基金面上项目：转录因子 ThPOK在 T 细胞发育分化中的功能和机制。

3. 2011年国家重大科学研究计划“中胚层干细胞自我更新分化的机制与功能研究”第三课题组组长。

4. 2012年国家自然科学基金-优秀青年项目“分子免疫/T细胞发育”。

5. 2014年国家重大研究计划“组织免疫”培育项目。

6. 2015年国家重大科学研究计划项目“母-胎界面交互对话异常致妊娠相关重大疾病的分子机制”参与者。

7. 2017年国家自然科学基金面上项目：表观调控因子CFP1 在T 细胞分化发育中的机制研究。

8. 2019年国家自然科学基金面上项目：DNA损伤结合蛋白DDB1及其底物识别蛋白DCAF2复合体在B淋巴细胞发育过程中的功能机制研究。

9. 2021年国家自然科学基金重点项目：新型核仁蛋白在T淋巴细胞中的功能机制研究。

10.2021年浙江省自然科学基金重点项目：表观调控蛋白CFP1 在Treg 细胞中机制研究。

 

1.Lina Zhou, Shuai Wang, Wei Hu, Xiaoqian Liu, Lingdong Xu, Bolu Tong, Tongtong Zhang, Zhonghui Xue, Yixin Guo, Jing Zhao, Linrong Lu, Hengyu Fan, Wenbin Qian, Jian Chen, Wei Chen*, Lie Wang*. T cell proliferation requires ribosomal maturation in nucleolar condensates dependent on DCAF13. J Cell Biol. 2023 Oct 2;222(10):e202201096.

2.Xin Shen, Xianzhi Gao, Yikai Luo, Qianying Xu, Ying Fan, Shenghui Hong, Zhengwei Huang, Xiaoqian Liu, Qianqian Wang, Zuojia Chen, Di Wang, Linrong Lu, Chuan Wu*, Han Liang*, Lie Wang*. Cxxc finger protein 1 maintains homeostasis and function of intestinal group 3 innate lymphoid cells with aging. Nat Aging. 2023 Aug;3(8):965-981.

3. Jing Chen, Kuai Liu, Yikai Luo, Muxing Kang, Jun Wang, Guofeng Chen, Jia Qi, Wenxuan Wu, Beidi Wang, Yaxuan Han, Le Shi, Kefan Wang, Xiaying Han, Xiaojing Ma, Wei Liu, Yuan Ding, Liangjing Wang, Han Liang*, Lie Wang*, Jian Chen*. Single-cell Profiling of Tumor Immune Microenvironment Reveals Immune Irresponsiveness in Gastric Signet-ring Cell Carcinoma. Gastroenterology. 2023 Mar 13;S0016-5085(23)00262-7.

4.Jing CHEN, Jian CHEN*,and Lie Wang*,Tertiary lymphoid structures as unique constructions associated with the organization, education, and function of tumor-infiltrating immunocytes. J Zhejiang Univ Sci B. 2022 Oct 15;23(10):812-82

5. Xianzhi Gao, Xin Shen, Kuai Liu, Chenyu Lu, Ying Fan, Qianying Xu, Xiaoyu Meng, Shenghui Hong, Zhengwei Huang, Xia Liu, Linrong Lu and Lie Wang*, The Transcription Factor ThPOK Regulates ILC3 Lineage Homeostasis and Function During Intestinal Infection. Front Immunol. 01 July 2022

6.Jing Guo, Zhonghui Xue, Lie Wang*, Transcriptional regulation of the immune checkpoints PD-1 and CTLA-4. Cell Mol Immunol. 2022 Jul;19(7):861-862.

7.Yun Zhao, Juan Xiong, Hai-Xia Chen, Min Zhang, Li-Na Zhou, Yin-Fang Wu, Wei-Jie Li, Xia Fei, Fei Li, Chen Zhu, Wen Li, Song-Min Ying, Lie Wang*, Zhi-Hua Chen*, Hua-Hao Shen*, A Spontaneous H2-Aa Point Mutation Impairs MHC II Synthesis and CD4 + T-Cell Development in Mice. Front Immunol. 2022 Mar 4;13:810824

8.Jun Wang, Beidi Wang, Biting Zhou, Jing Chen, Jia Qi, Le Shi, Shaojun Yu, Guofeng Chen, Muxing Kang, Xiaoli Jin, Lie Wang, Jinghong Xu, Linghua Zhu, Jian Chen, novel immune-related lncRNA pair signature for prognostic prediction and immune response evaluation in gastric cancer: a bioinformatics and biological validation study. Cancer Cell Int. 2022 Feb 10;22(1):69.

9.Lize Wu, Ziwei Xue, Siqian Jin, Jinchun Zhang, Yixin Guo, Yadan Bai, Xuexiao Jin, Chaochen Wang, Lie Wang, Zuozhu Liu, James Q Wang, Linrong Lu, Wanlu Liu, huARdb: human Antigen Receptor database for interactive clonotype-transcriptome analysis at the single-cell level. Nucleic Acids Res. 2022 Jan 7;50(D1):D1244-D1254.

10.Jie Yang, Hongkai Zhang, Xuelian Wang, Jing Guo, Lin Wei, Yahui Song, Yuan Luo, YinXia Zhao, Malayannan Subramaniam, Thomas C Spelsberg, Lie Wang*, Wei Xu*, Min Li*. Kruppel-like factor 10 protects against acute viral myocarditis by negatively regulating cardiac MCP-1 expression. Cell Mol Immunol. 2020 Sep 7. doi: 10.1038/s41423-020-00539-x.

11.Jun Wang, Shaojun Yu, Guofeng Chen, Muxing Kang, Xiaoli Jin, Yi Huang, Lele Lin, Dan Wu, Lie Wang*, Jian Chen*. A novel prognostic signature of immune-related genes for patients with colorectal cancer. J Cell Mol Med. 2020 Aug;24(15):8491-8504.

12. Jie-Sen Zhou, Zhou-Yang Li, Xu-Chen Xu, Yun Zhao, Yong Wang, Hai-Pin Chen, Min Zhang, Yin-Fang Wu, Tian-Wen Lai, Chun-Hong Di, Ling-Ling Dong, Juan Liu, Nan-Xia Xuan, Chen Zhu, Yan-Ping Wu, Hua-Qiong Huang, Fu-Gui Yan, Wen Hua, Yi Wang, Wei-Ning Xiong, Hui Qiu, Tao Chen, Dong Weng, Hui-Ping Li, Xiaobo Zhou, Lie Wang, Fang Liu, Xin Lin, Song-Min Ying, Wen Li, Mitsuru Imamura, Mary E Choi, Martin R Stampfli, Augustine M K Choi, Zhi-Hua Chen, Hua-Hao Shen. Cigarette smoke-initiated autoimmunity facilitates sensitisation to elastin-induced COPD-like pathologies in mice. Eur Respir J. 2020 Sep 3;56(3):2000404.

13. Yiwen Zhang, Yingshi Chen, Rong Ma, Yawen Jiang, Jun Liu, Yingtong Lin, Siqi Chen, Mengying Xia, Fan Zou, Junsong Zhang, Ting Pan, Lie Wang, Lai Wei, Hui Zhang. UHRF1 Controls Thymocyte Fate Decisions through the Epigenetic Regulation of EGR1 Expression. J Immunol. 2020 Jun 15;204(12):3248-3261.

14.Zhonghui Xue, Jing Guo, Ruoyu Ma, Lina Zhou, Yixin Guo, Yong Cang, Hengyu Fan, Jian Chen, Wenbin Qian, Lie Wang*. The DDB1-DCAF2 Complex Is Essential for B Cell Development Because It Regulates Cell Cycle Progression. Cellular & Molecular Immunology. 2020 Mar 5. DOI: 10.1038/s41423-020-0390-2

15.Jun Lyu, Lie Wang, Linrong Lu. Thymocyte Selection: From Signaling to Epigenetic Regulation. Adv Immunol, 2019, 144, 1-22.

16. Feng Lin, Xiaoyu Meng, Yixin Guo, Wenqiang Cao, Wanlu Liu, Qiming Xia, Zhaoyuan Hui, Jian Chen, Shenghui Hong, Xuliang Zhang, Chuan Wu, Di Wang, Jianli Wang, Linrong Lu, Wenbin Qian, Lai Wei, and Lie Wang*. Epigenetic initiation of the TH17 differentiation program is promoted by Cxxc finger protein 1. Sci Adv. 2019 Oct; 5(10): eaax1608.

17.Jing Guo, Zhonghui Xue, Ruoyu Ma, Weiwei Yi, Zhaoyuan Hui, Yixin Guo, Yuxi Yao, Wenqiang Cao, Jianli Wang, Zhenyu Ju, Linrong Lu and Lie Wang*. The transcription factor Zfp281 sustains CD4+ T lymphocyte activation through directly repressing Ctla-4 transcription. Cellular & Molecular Immunology. 2019 Sep 11. doi: 10.1038/s41423-019-0289-y.

18.Mingzhu Zheng, Dan Li, Zhishan Zhao, Dmytro Shytikov, Qin Xu, Xuexiao Jin, Jingjing Liang, Jun Lou, Songquan Wu, Lie Wang, Hu Hu, Yiting Zhou, Xiang Gao, Linrong Lu. Protein Phosphatase 2A Has an Essential Role in Promoting Thymocyte Survival During Selection. Proc Natl Acad Sci U S A, 2019 Jun 18,116 (25), 12422-12427. 

19.Xu Q, Jin X, Zheng M, Rohila D, Fu G, Wen Z, Lou J, Wu S, Sloan R, Wang L, Hu H, Gao X*, Lu L*. Phosphatase PP2A is essential for TH17 differentiation. Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):982-987.

20.Yin S, Yu J, Hu B, Lu C, Liu X, Gao X, Li W, Zhou L, Wang J, Wang D, Lu L, Wang L*. Runx3 Mediates Resistance to Intracellular Bacterial Infection by Promoting IL12 Signaling in Group 1 ILC and NCR+ILC3. Front Immunol. 2018 Sep 12;9:2101.

21.  Hui Z, Zhou L, Xue Z, Zhou L, Luo Y, Lin F, Liu X, Hong S, Li W, Wang D, Lu L, Wang J, Wang L*.Cxxc Finger Protein 1 Positively Regulates GM-CSF-Derived Macrophage Phagocytosis Through Csf2rα-Mediated Signaling. Front Immunol. 2018 Aug 14;9:1885.

22.  Yu C, Fan X, Sha QQ, Wang HH, Li BT, Dai XX, Shen L, Liu J, Wang L, Liu K, Tang F, Fan HY. CFP1 Regulates Histone H3K4 Trimethylation and Developmental Potential in Mouse Oocytes. Cell Rep. 2017 Aug 1;20(5):1161-1172.

23.  Liang J, Lyu J, Zhao M, Li D, Zheng M, Fang Y, Zhao F, Lou J, Guo C, Wang L, Wang D, Liu W, Lu L. Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors. Nat Commun. 2017 Jun 9;8:15732.

24.  Cao W, Guo J, Wen X, Miao L, Lin F, Xu G, Ma R, Yin S, Hui Z, Chen T, Guo S, Chen W, Huang Y, Liu Y, Wang J, Wei L*,Wang L*. CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation. Nat Commun. 2016 May 23;7:11687.

25.  Vacchio MS, Lie Wang, Bouladoux N, Carpenter AC, Xiong Y, Williams LC, Wohlfert E, Song KD, Belkaid Y, Love PE, Bosselut R.A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells. Nat Immunol. 2014 15(10): 947–956.

26.  Xia Liu, Shengxia Yin, Wenqiang Cao, Wei Fan, Lei Yu, Li Yin, Lie Wang*, and Jianli Wang*. Runt-related transcription factor 3 is involved in the altered phenotype and function in ThPok-deficient invariant natural killer T cells. Cell Mol Immunol. 2014 11(3):232-44.

27.  Zhang W, Wang X, Xia X, Liu X, Suo S, Guo J, Li M, Cao W, Cai Z, Hui Z, Subramaniam M, Spelsberg TC, Wang J, Lie Wang*. Klf10 inhibits il-12p40 production in m-csf-induced mouse bone marrow-derived macrophages. Eur J Immunol. 2013 Jan;43(1):258-69.

28.  Min Li, Wenqiang Cao, Haifeng Liu, Wei Zhang, Xia Liu, Zhijian Cai, Jing Guo, Xuelian Wang, Zhaoyuan Hui, Hang Zhang, Jianli Wang and Lie Wang*, MCPIP1 down-regulates IL-2 expression through an ARE-independent pathway. PLoS One. 2012;7(11):e49841.

29. Carpenter AC, Grainger JR, Xiong Y, Kanno Y, Chu HH, Lie Wang, Naik S, Dos Santos L, Wei L, Jenkins MK, O'Shea JJ, Belkaid Y, Bosselut R. The transcription factors thpok and lrf are necessary and partly redundant for t helper cell differentiation. Immunity 2012,37:622-633.

30. Cai Z, Zhang W, Yang F, Yu L, Yu Z, Pan J, Lie Wang, Cao X, Wang J. Immunosuppressive exosomes from tgf-beta1 gene-modified dendritic cells attenuate th17-mediated inflammatory autoimmune disease by inducing regulatory t cells. Cell Res 2012,22:607-610.

31. Cai Z, Yang F, Yu L, Yu Z, Jiang L, Wang Q, Yang Y, Lie Wang, Cao X, Wang J. Activated t cell exosomes promote tumor invasion via fas signaling pathway. J Immunol 2012,188:5954-5961.

32.   Shen H, Tang Y, Xu X, Lie Wang, Wang Q, Xu W, Song H, Zhao Z, Wang J. Rapid detection of neoplastic cells in serous cavity effusions in children with flow cytometry immunophenotyping. Leuk Lymphoma. 2012,53:1509-1514.

33. Wang D, Zheng MZ, Lei L, Ji J, Yao YL, Qiu YJ, Ma L, Lou J, Ouyang C, Zhang X, He YW, Chi J, Lie Wang, Kuang Y, Wang JL, Cao XT, Lu LR. Tespa1 is involved in late thymocyte development through the regulation of tcr-mediated signaling. Nat Immunol 2012,13(6):560-8.

34. Adoro S, McCaughtry T, Erman B, Alag A, Van Laethem F, Park JH, Tai X, Kimura M, Lie Wang, Grinberg A, Kubo M, Bosselut R, Love P, Singer A. Coreceptor gene imprinting governs thymocyte lineage fate. The EMBO Journal2011,31(2):366-77.

35. Lie Wang, Xiong Y, Bosselut R. Maintaining CD4-CD8 lineage integrity in T cells: where plasticity serves versatility.Semin Immunol 2011,23(5):360-7.

36. Lie Wang, Tiffany Carr, Yumei Xiong, Kathryn F Wildt, Jinfang Zhu, Lionel Feigenbaum, Albert bendelac, & Rémy Bosselut.  The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4(+) NKT cells. Eur J immunol 2010,40(9):2385-2390.

37. Lie Wang, Yumei Xiong and Rémy Bosselut.  Tenuous paths in unexplored territory: From T cell receptor signaling to effector gene expression during thymocyte selection. Semin Immunol 2010,22(5): 294-302.

38. Lie Wang and Rémy Bosselut.  CD4-CD8 lineage differentiation: Thpok-ing into the nucleus. J Immunol. 2009 183(5):2903-10.

39. Renaud Lesourne, Shoji Uehara, Jan Lee, Ki-Duk Song, LiQi Li, Julia Pinkhasov, Yongqing Zhang, Nan-Ping Weng, Kathryn F Wildt, Lie Wang, Remy Bosselut & Paul E Love.  Themis, a T cell–specific protein important for late thymocyte development. Nature Immunology 2009,10, 840–847.

40. Lie Wang, Kathryn F Wildt, Jinfang Zhu, Xianyu Zhang, Lionel Feigenbaum, Lino Tessarollo, William E Paul, B J Fowlkes & Rémy Bosselut.  Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4 (+) T cells. Nature Immunol 2008,9(10): 1122-30.

41. Lie Wang, Kathryn F. Wildt, Ehydel Castro, Yumei Xiong, Lionel Feigenbaum, Lino Tessarollo and Rémy Bosselut.  The zinc finger transcription factor Zbtb7b (Thpok, cKrox) represses CD8-lineage gene expression in peripheral CD4 T cells.Immunity 2008,29(6):876-87.