浙江大学, 医学院附属儿童医院, 副研究员

 

(1) 2012-08 至 2017-07, 清华大学, 基础医学, 博士

(2) 2008-09 至 2012-06, 湖北师范大学, 生物, 学士

 

(1) 2017-07 至 2020-07, 清华大学，博士后

(2) 2020-07 至 今, 浙江大学, 医学院附属儿童医院, 副研究员

 

中国药理学会生化与分子药理学专业委员会青年委员

浙江省神经科学学会青年委员

 

(1) 国家自然科学基金委员会, 青年科学基金项目, 82200784, 基于肾脏类器官研究CLCN5突变介导脂代谢

异常致1型Dent病的作用机制, 2023-01-01 至 2025-12-31, 30万元, 在研, 主持

(2) 国家自然科学基金委员会, 面上项目, 32271311, PNLDC1介导内质网mRNA代谢的调控机制和功能研究,

2023-01-01 至 2026-12-31, 54万元, 在研, 主持

(3) 浙江省科学技术厅, 重点研发计划, 2023C03027, 早衰症儿童多模态评估体系建立及干预策略研究, 2

023-01 至 2025-12, 400万元, 在研, 主持

(4) 浙江省卫生厅中医药管理局, 重点项目, GZY-ZJ-KJ-23083, 曲克芦丁介导应激颗粒在预防和治疗新冠

病毒的应用, 2023-01 至 2025-12, 10万元, 在研, 主持

(5) 浙江省基础公益研究, 探索项目, No. LQ22C070004, γA 晶状体蛋白的生理功能及其遗传突变 I82M

致白内障的分子机制, 2022-01 至 2024-12, 10万元, 在研, 主持

 

(1) Hu, Li-Dan; Wang, Jing; Chen, Xiang-Jun; Yan, Yong-Bin ; Lanosterol modulates proteostasis via dissolving cytosolic sequestosomes/aggresome-like induced structures., Biochimica et Biophysica Acta-Molecular CellResearch, 2020, 1867(2): 118617 (期刊论文)

(2) Hu, Li-Dan; Chen, Xiang-Jun; Liao, Xiao-Yan; Yan, Yong-Bin ; Screening novel stress granule regulators from a natural compound library., Protein & Cell, 2017, 8(8): 618-622 (期刊论文)

(3) Wanyue Xu; Jingjie Xu; Caiping Shi; Jing Wu; Huaxia Wang; Wei Wu; Xiangjun Chen; Hu,Li-dan ; A novel cataract-causing mutation Ile82Met of γA crystallin trends to aggregate with unfolding intermediate, Int J Biol Macromol, 2022, 04(205): 357-367 (期刊论文)

(4) Fan Yu; Li Lin; Jingmiao Sun; Jicheng Pan; Yixin Liao; Yunfan Pan; Guannan Bai; Liangjian Ma; Jianhua Mao; Lidan Hu ; Cysteine Pathogenic Variants of PMM2 Are Sensitive to Environmental Stress with Loss of Structural Stability, Oxidative Medicine and Cellular Longevity, 2023, 2023: 1-17 (期刊论文)

(5) Qi, Liang-Bo; Hu, Li-Dan; Liu, Huihui; Li, Hai-Yun; Leng, Xiao-Yao; Yan, Yong-Bin ; Cataract-causing mutation S228P promotes βB1-crystallin aggregation and degradation by separating two interacting loops in C-terminal domain., Protein & Cell, 2016, 7(7): 501-515 (期刊论文)

(6) Zhao, Ling; Chen, Xiang-Jun; Zhu, Jie; Xi, Yi-Bo; Yang, Xu; Hu, Li-Dan; Ouyang, Hong; Patel, Sherrina H; Jin, Xin; Lin, Danni; Wu, Frances; Flagg, Ken; Cai, Huimin; Li, Gen; Cao, Guiqun; Lin, Ying; Chen, Daniel; Wen, Cindy; Chung, Christopher; Wang, Yandong; Qiu, Austin; Yeh, Emily; Wang, Wenqiu; Hu, Xun; Grob, Seanna; Abagyan, Ruben; Su, Zhiguang; Tjondro, Harry Christianto; Zhao, Xi-Juan; Luo, Hongrong; Hou, Rui; Jefferson, J; Perry, P; Gao, Weiwei; Kozak, Igor; Granet, David; Li, Yingrui; Sun, Xiaodong; Wang, Jun; Zhang, Liangfang; Liu, Yizhi; Yan, Yong-Bin; Zhang,Kang ; Lanosterol reverses protein aggregation in cataracts., Nature, 2015, 523(7562): 607-611(期刊论文)

(7) Langping Gao; Fangqin Wang; Yan Wang; Lidan Hu; Jianhua Mao ; A protocol for the generation of patient-specific iPSC lines from peripheral blood mononuclear cells., STAR protocols, 2022,3(3): 101530-101530 (期刊论文)

(8) Yunfan Pan; Li Lin; Fan Yu; Jingmiao Sun; Guannan Bai; Xinyu He; Jianhua Mao; Lidan Hu ;Cysteine mutations impair the structural stability of phosphomannomutase 2 (PMM2) in glycosylation-associated metabolic disorders, Genes and Diseases, 2022, 10(002): 1-3 (期刊论文)