长期从事细胞膜损伤感应和修复机制研究，重点关注多细胞动物体 内细胞膜和亚细胞器在分子水平快速感应局部细胞膜损伤、释放胞内外信号调 控细胞膜损伤修复的分子机制。实验室建立了线虫表皮多核细胞在体细胞膜损伤感应和修复模型，围绕损伤感应和修复的 动态调控机制开展了系统性研究，取得了一系列原创性成果。近年来以通讯作者已发表包括 Developmental Cell(2020，2022)，Nature Communications(2020)，Cell Reports(2021)，eLife(2023)等多篇研究论文。应邀撰写领域内相关综述论文和方法学论文。此外，还参与多项合作，在 Nature Communications, Current Biology，Neuron，Cell Reports 和 eLife 等国际知名杂志发表了多篇合作研究论文。

 

2009.06-2014.05 加州大学圣地亚哥分校（UCSD），博士后

2003.09-2009.04 中国科学院遗传与发育生物学研究所，博士

1999.09-2003.07 武汉大学，本科

 

国家级青年人才项目

浙江省杰出青年基金

 

中国细胞生物学学会发育生物学专业委员会委员

中国动物学学会发育生物学专业委员会副主任委员

中国生物物理学会亚细胞结构与功能专业委员会理事

中国生物物理学会线粒体专业委员会理事

中国生物物理学会膜生物学专业委员会理事

 

近五年主持或参加的国家级课题:

(1) 国家自然科学基金委员会, 重大研究计划, 92254303, 细胞器互作调控膜完整性稳态的机制研究

(2) 国家自然科学基金委员会, 面上项目, 31972891, 线粒体片段化加速线虫皮肤损伤修复的机制研究 

(3) 中华人民共和国科技部, 国家重点研发计划, 2021YFA1300300, 细胞内膜系统完整性的稳态调控机制

(4) 中华人民共和国科技部, 国家重点研发计划, 2021YFA1101000, 皮肤干细胞异质性和命运调控的分子 机制及临床转换研究

 

1.  Yuanyuan Wang, Qingxian Yang, Xinan Meng, Chandra Sugiarto Wijaya, Xuecong Ren, and Suhong Xu (2022) Recruitment of tetraspanin TSP-15 to epidermal wounds promotes plasma membrane repair in C. elegans, Developmental Cell Jun 30th 2022 https://doi.org/10.1016/j.devcel.2022.06.004

2.  Xu Jingxiu, Meng Xinan, Yang Qingxian, Zhang Jianqin, Hu Wei, Fu Hongying, Chen Jack Wei, Ma Weirui, Chisholm Andrew, Sun Qiming, and Xu Suhong (2021) Redox-sensitive CDC-42 clustering promotes wound closure in C. elegans, Cell Reports 37, 110040 Nov 23, 2021 https://doi.org/10.1016/j.celrep.2021.110040

3.  Ma yicong, Xie jing, Wijaya Chandra, and Xu Suhong. (2020) From wound response to repair – lessons from C. elegans, Cell Regeneration, DOI : 10.1186/s13619-020-00067-z

4.  Wijaya CS, Meng X, Yang Q, Xu S. (2020) Protocol to Induce Wounding and Measure Membrane Repair in Caenorhabditis elegans Epidermis. STAR Protocols, 100175

5.  Zhao Jianzhi, Wang Xiaojie, Meng Xinan, Zou Wei, and Xu Suhong, Rapid and efficient wounding for in vivo studies of neuronal dendrite regeneration and degeneration, Journal of Genetics and Genomics, 2020.

6.  Meng Xinan, Yang Qingxian, Yu Xinghai, Zhou Jinghua, Ren Xuecong, Zhou Yu, and Xu Suhong (2020) Actin polymerization and ESCRT trigger recruitment of the fusogens Syntaxin-2 and EFF-1 to promote membrane repair in C. elegans, Developmental Cell, 2020. Sep 14;54(5):624-638

7.  Fu Hongying, Zhou Hengda, Yu Xinghai, Zhou Jinghua, Xu Jingxiu, Meng Xinan, Zhao Jianzhi, Zhou Yu, Chisholm Andrew D., and Xu Suhong (2020) Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative metabolic signaling, Nature Communications, 2020.11:1050

8.  Tang NH, Kim KW, Xu S, Blazie SM, Yee BA, Yeo GW, Jin Y, Chisholm AD (2020) The mRNA Decay Factor CAR-1/LSM14 Regulates Axon Regeneration via Mitochondrial Calcium Dynamics. Curr Biol. 2020 Mar 9;30(5):865-876.e7.

9.  Xinan Meng, Jingxiu Xu, and Suhong Xu (2019) Advances in tissue repair and regeneration, Chinese Journal of Cell Biology, 2019, 41(9):1680-1689.

10.  Xinan Meng, Hengda Zhou, and Suhong Xu (2017) CRISPR-Cas9 mediated genome editing in Caenorhabditis elegans. Chinese Journal of Biotechnology, 2017, 33(10): 1693-1699. (In Chinese)

11.  Chuang M, Hsiao TI, Tong A, Xu S, Chisholm AD (2016) DAPK interacts with Patronin and the microtubule cytoskeleton in epidermal development and wound repair. Elife. 2016 Sep 23;5:e15833. doi: 10.7554/eLife.15833.

12.  Xu S, Chisholm AD (2016) Highly efficient optogenetic cell ablation in C. elegans using membrane-targeted miniSOG. Scientific Reports 6, 21271; doi: 10.1038/srep21271

13.  Xu S, Wang Z, Kim KW, Jin Y and Chisholm AD (2016) Targeted mutagenesis of duplicated genes in C. elegans using CRISPR-Cas9. J. Genetics and Genomics http://dx.doi.org/10.1016/j.jgg.2015.11.004

14.  Xu S. (2015) The application of CRISPR-Cas9 genome editing in Caenorhabditis elegans, J. Genetics and Genomics, (invited review) Aug 20; 42(8): 413-21.  

15.  Xu Suhong, Chisholm AD (2014) C. elegans epidermal wounding induces a mitochondrial ROS burst that promotes wound repair. Developmental Cell. 2014 Oct 13; 31:48-60.

16.  Xu Suhong, Chisholm AD (2014) Methods for skin wounding and assays for wound responses in C. elegans. JoVE, e51959, doi:10.3791/51959 (2014).

17.  Chisholm AD, Xu Suhong (2012) The Caenorhabditis elegans epidermis as a model skin. II: differentiation and physiological roles. WIREs Dev Biol 2012. doi: 0.1002/wdev.77

18.  Xu Suhong, Hsiao T, Chisholm AD. (2012) The wounded worm: Using C. elegans to understand the molecular basis of skin wound healing. Worm 1:2, 1–5; April/May/June

19.  Xu Suhong, Cheng F, Liang J, Wu W, Zhang J.(2012) Maternal xNorrin, a canonical Wnt signaling agonist and TGF-β antagonist, controls early neuroectoderm specification in Xenopus. PLoS Biol. 2012 Mar;10(3):e1001286.

20.  Xu Suhong, Chisholm AD (2011) A Gαq-Ca²⁺ signaling pathway promotes actin-mediated epidermal wound closure in C. elegans. Curr Biol. 2011 Dec 6;21(23):1960-7.

 

在读博士6人，在读硕士3人，已毕业博士3人