吴海滨，博士，研究员，杭州医学院研究生导师（wuhaibin@hmc.edu.cn）。入选浙江省省级人才、杭州医学院“求真人才工程”三层次人才，主要致力于新型药物递送系统可控设计与应用研究。研究方向主要以临床未满足需求与重大疾病为导向，针对蛋白质、核酸、疫苗等新型药物递送过程的基础科学问题进行实验探索与理论阐释，构建安全、高效的新型生物制剂。近年以第一作者或通讯作者身份在Advanced Materials、Advanced Science（封面文章）、 ACS Central Science（封面文章，SCI高被引）、Nano Today等国际一流期刊发表多篇论文，引用超1000次，获授权国家发明专利3项。近年来，获国家自然科学基金青年基金、浙江省自然科学基金基础公益研究项目、中国博士后科学基金等项目的资助。

 

博士：2013.09-2019.06  浙江大学 药学院 药物制剂研究所

学士：2009.09-2013.06  中国药科大学 药学院 药剂学专业

 

2022.05-至今 杭州医学院药学院  研究员

 

2019.07-2022.04  浙江大学药学院  助理研究员（博士后）

 

浙江省营养学会第一届中医药养生与营养专业委员会委员

 

1、国家自然科学基金（32201161），纳米酶协同增强CRISPR/Cas9精准长效抗炎疗法的设计构建及其在类风湿关节炎中的应用研究，2023.01-2025.12

 

2、杭州医学院“求真人才工程”项目（第三层次），2022.05-2027.05

 

3、杭州医学院基本科研业务费基础科研项目（重点科研基金），基于纳米催化效应的 银屑病“催化基因”双模态协同抗炎疗法，2023.03-2026.03

 

4、浙江省自然科学基金（LQ21H300004），基于纳米酶的miRNA自保护递送系统构建及其在脓毒症协同治疗中的研究，2021.01-2023.12

 

5、中国博士后科学基金（2020M671774），纳米酶嵌入式自保护miRNA递送系统构建及其在银屑病协同治疗中的研究，2020.06-2022.06

 

(1)  Haibin Wu1*, Shuhan Shi1, Lenan Xu1, Ziying Zheng, Ziyan Huang, Yi Qiu, Jixiang Zhang, Keyun Yang, Yuting Xie, Cheng Xu, Tianyang Xu, Guohuan Zeng, Lingfeng Chen, Mincong Huang, Qian Chen*, Daishun Ling*, Guang Liang*. Nanozyme engineered ROS-tolerant cysteine active-site for upstream deubiquitylation therapy of inflammatory bowel disease. Nano Today, 2025, 62: 102735. ( IF = 13.2; 共同通讯; 中科院分区: 1区, TOP期刊)

(2) Weitong Hu1, Shuhan Shi1, Yihua Xu, Yunting Zhang, Jingyi Hu, Qiong Bian, Xiaolu Ma, Yuxian Ye, Shengfei Yang, Xiaoxia Sheng, Guang Liang, Tianyuan Zhang, Haibin Wu*, Jianqing Gao*. Platinum Nanozyme-Loaded Dissolving Microneedles Scavenge ROS and Promote Lineage Progression for Androgenetic Alopecia Treatment. Small Methods, 2024, 2401176. (IF = 10.7; 共同通讯)

(3) Haibin Wu1, Min Wei1, Shen Hu1, Pu Cheng, Shuhan Shi, Fan Xia, Lenan Xu, Lina Yin, Guang Liang*，Fangyuan Li*, Daishun Ling*. A Photomodulable Bacteriophage-Spike Nanozyme Enables Dually Enhanced Biofilm Penetration and Bacterial Capture for Photothermal-Boosted Catalytic Therapy of MRSA Infections. Advanced Science, 2023, 2301694. （IF=17.521; 中科院分区: 1区, TOP期刊；封面文章）

(4) Haibin Wu1, Fan Xia1, Lingxiao Zhang1, Chunyan Fang, Jiyoung Lee, Linji Gong, Jianqing Gao*, Daishun Ling*, Fangyuan Li*. A ROS-sensitive nanozyme-augmented photoacoustic nanoprobe for early diagnosis and therapy of acute liver failure. Advanced Materials, 2022, 34(7): e2108348. (IF=30.849; 中科院分区: 1区, TOP期刊)

(5) Haibin Wu1, Fangyuan Li1, Wei Shao, Jianqing Gao*, Daishun Ling*. Promoting angiogenesis in oxidative diabetic wound microenvironment using a nanozyme-reinforced self-protecting hydrogel. ACS Central Science, 2019, 5: 477-485. (IF=14.553; 中科院分区: 1区, TOP期刊；封面文章)

(6) Haibin Wu1, Fangyuan Li1, Shuaifei Wang, Jingxiong Lu, Jinquan Li, Yang Du, Xiaolian Sun, Xiaoyuan Chen, Jianqing Gao*, Daishun Ling*. Ceria nanocrystals decorated mesoporous silica nanoparticle based ROS-scavenging tissue adhesive for highly efficient regenerative wound healing. Biomaterials, 2018, 151: 66-77. (IF= 12.479; 中科院分区: 1区, TOP期刊)

(7) Haibin Wu1, Hongwei Liao1, Fangyuan Li*, Jiyoung Lee, Pingjing Hu, Wei Shao, Xiangzi Li, Daishun Ling*. Bioactive ROS-scavenging nanozymes for regenerative medicine: Reestablishing the antioxidant firewall. Nano Select, 2020, 1: 285-297.

(8) Tianyuan Zhang, Bing Huang, Haibin Wu, Jiahe Wu, Liming Li, Yanxin Li, Yulan Hu, Min Han, Youqing Shen, Yasuhiko Tabata, Jianqing Gao*. Synergistic effects of co-administration of suicide gene expressing mesenchymal stem cells and prodrug-encapsulated liposome on aggressive lung melanoma metastases in mice. Journal of Controlled Release, 2015, 209: 260-271. (IF=9.776; 中科院分区: 1区)

(9) Anran Yuan, Fan Xia, Qiong Bian, Haibin Wu, Yueting Gu, Tao Wang, Ruxuan Wang, Lingling Huang, Qiaoling Huang, Yuefeng Rao, Daishun Ling, Fangyuan Li*, and Jianqing Gao*. Ceria nanozyme-integrated microneedles reshape the perifollicular microenvironment for androgenetic alopecia treatment. ACS Nano, 2021, 15(8): 13759-13769. (IF=15.881; 中科院分区: 1区, TOP期刊)

(10) Youkun Zheng, Min Wei, Haibin Wu, Fangyuan Li*, Daishun Ling*. Antibacterial metal nanoclusters. Journal of Nanobiotechnology, 2022, 20(1): 1-19. (IF=9.429; 中科院分区: 1区)

(11) Shuaifei Wang, Fangyuan Li, Ruirui Qiao, Xi Hu, Hongwei Liao, Lumin Chen, Jiahe Wu, Haibin Wu, Meng Zhao, Jianan Liu, Rui Chen, Xibo Ma, Dokyoon Kim, Jihong Sun, Thomas P. Davis, Chunying Chen, Jie Tian, Taeghwan Hyeon, and Daishun Ling*. Arginine-Rich manganese silicate nanobubbles as a ferroptosis-inducing agent for tumor-targeted theranostics. ACS Nano, 2018, 12(12): 12380-12392. (IF=15.881; 中科院分区: 1区, TOP期刊)