姓  名:
陶然
工作单位:
附属人民医院
职  称:
主任医师
职  务:
副主任
办公电话:
13301919116
邮  箱:
15755261776@163.com
学科专业:
基础医学
研究方向:
普通外科
个人简介

美国外科学院(ACS)Fellow(FACS),青年委员会(YFC)成员 美国移植学会(AST)会员 美国移植外科医师协会(ASTS)会员 移植协会(TTS)会员 国际肝胆胰外科协会(IHPBA)中国分会胆道结石专家委员会委员 上海医学会外科分会 青年委员 浙江省医学会器官移植分会委员 浙江省医师协会器官移植分会委员 上海市教育委员会 外科学特聘教授(“东方学者”) 上海交大医学院 外科学博士生导师 苏州大学医学院 外科学博士生导师 中国医科大学外科学博士生导师 蚌埠医学院 外科学硕士生导师 浙江省“千人计划”特聘专家(创新长期) 浙江省“杰出青年基金”获得者 浙江大学-加州国际纳米技术研究院特聘专家 浙江中医药大学兼职教授 绍兴文理学院“鉴湖学者”讲席教授 绍兴文理学院附属医院、绍兴市立医院特聘专家 HBPD Int(国际肝胆胰疾病)编委 World Journal of Gastrointestinal Surgery编委 International Journal of Immunology编委 World Journal of Hepatology编委 国家自然科学基金评审专家 上海市、浙江省、广东省自然科学基金评审专家

 

教育背景

1992.09-1997.07 浙江医科大学,医学系本科学习 医学学士学位

1997.09-2000.06 浙江大学医学院,攻读普外科硕士学位 外科学硕士学位

2006.03 美国外国医学毕业生教育委员会(ECFMG)(USMLE ID: 0-681-0220)  医学博士学位(MD)


 

工作经历

1、2000~2001年为浙江大学医学院附属第一医院肝胆胰外科、肝移植中心医师,同时负责临床医学系学生的普通外科临床见习和实习的带教工作

2、2003~2007年作为宾夕法尼亚大学及费城儿童医院病理和实验医学系的博士后研究员,协助导师Wayne W. Hancock教授做好对多名免疫学博士研究生和在实验室轮转的临床医生的实验指导

3、2007~2009年在匹兹堡大学医学中心移植外科任ASTS腹部多器官移植临床研究员期间,负责普通外科、泌尿外科、整形外科住院医生、高年级医学生和进修医生的临床教学和培训

4、参加上海交通大学医学院8年制医学生的外科学教学,讲授“肝脏疾病的外科治疗”;参加“上消化道出血”的PBL教学

5、参加上海交通大学医学院危重症护理国家级学习班的教学,讲授“肝脏移植”

6、参加传染科国家级继续教育学习班,讲授“肝脏移植”

7、积极参与医学生和研究生的临床带教参加硕、博士研究生的科研指导

8、2010/3被聘为上海交大医学院外科学博士研究生导师

9、多次担任外校硕、博士研究生的答辩委员会成员

10、2010年 上海交通大学医学院PBL教案大赛英文教案特等奖

11、2010年 上海交大医学院外科学全英语示范教程  课程负责人

12、2011年 上海市全英语示范教程(外科学) 课程负责人

13、2011年 上海交通大学医学院“海外名师讲座课程”项目

14、2012年 上海交大医学院大学生创新训练计划(“联合抑制去乙酰化和甲基化对调节性T细胞核移植免疫耐受的调控作用”) 指导老师 

15、上海市大学生创新创业训练计划“联合抑制去乙酰化和甲基化对调节性T细胞核移植免疫耐受的调控作用”) 指导老师

 

16、2016-2021 蚌埠医学院外科学硕士生导师、苏州大学医学院外科学博士生导师、中国医科大学外科学博士生导师


 

成果荣誉

美国移植学会 (AST) 夏季论坛旅行奖





 

学术任职

美国外科学院(ACSFellowFACS),青年委员会(YFC)成员

美国移植学会(AST)会员



 

发表论文

(九)学术论文发表情况

 

发表的主要论著、影响因子和被引用情况:

 

1. Tiao MM, Lu L, Tao R, Harnaha J, Fung JJ, Huang LT, Qian S. Application of recipient-derived dendritic cells to induce donor-specific T-cell hyporesponsiveness. Transplant Proc. 2004; 36(5):1592-4. IF1.055,已被引用16)

2. Ye Q, Wang L, Wells AD, Tao R, Han R, Davidson A, Scott ML, Hancock WW. BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses. Eur J Immunol. 2004; 34(10): 2750-2759 IF5.179,已被引用158)

3. Tiao MM, Lu L, Tao R, Wang L, Fung JJ, Qian S. Prolongation of cardiac allograft survival by systemic administration of immature recipient dendritic cells deficient in NF-kappaB activity. Ann Surg. 2005; 241(3): 497-505. IF8.46,已被引用77次)

4. Tao R, Wang L, Han R, Wang T, Ye Q, Honjo T, Murphy TL, Murphy KM, Hancock WW. Differential effects of B and T lymphocyte attenuator (BTLA) and programmed death-1 on acceptance of partially versus fully MHC-mismatched cardiac allografts. J Immunol 2005; 175(9): 5774-82 IF6.387,已被引用133)

5. Tao R, Wang L, Chen CH, Wang SH, Demarco R, Lotze MT, Thai NL, Fung JJ, Lu L, Qian S. Mechanistic insights into achievement of cardiac allograft long-term survival by treatment with immature dendritic cells and subdose sirolimus. J Heart Lung Transplant. 2006; 25(3):310-9 IF5.112,已被引用4)

6. Tao R, de Zoeten EF, Ozkaynak E, Chen C, Wang L, Porrett PM, Li B, Turka LA, Olson EN, Greene MI, Wells AD, Hancock WW. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med. 2007; 13(11):1299-307. Epub 2007 Oct 7. IF28.6,已被引用823)

7. Li B, Samanta A, Song XM, Iacono KT, Bembas K, Tao R, Basu S, Riley JL, Hancock WW, Shen Y, Saouaf SJ, Greene MI. FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc Natl Acad Sci U S A. 2007; 104(11):4571-6. IF9.643,已被引用408)

8. Tao R, Wang L, Murphy KM, Fraser CC, Hancock WW. Regulatory T cell expression of HVEM suppresses the function of B and T lymphocyte attenuator-positive effector T cells. J Immunol. 2008; 180(10):6649-55. IF6.387,已被引用101)

9. Tao R, Hancock WW.  Resistance of Foxp3+ Regulatory T Cells to Nur77-induced apoptosis promotes allograft survival. PLoS One. 2008; 3(5):e2321. IF4.351,已被引用26)

10. Tao R, de Zoeten EF, Ozkaynak E, Wang L, Li B, Greene MI,  Wells AD, Hancock WW. Histone deacetylase inhibitors and transplantation. Curr Opin Immunol. 2007;19(5):589-595. Epub 2007 Aug 24. IF10.455,已被引用42)

11. Tao R, Hancock WW. Regulating regulatory T cells to achieve transplant tolerance. Hepatobiliary Pancreat Dis Int. 2007 6(4):348-57. IF1.183,已被引用40)

12. Tiao MM, Lu L, Huang LT, Liang CD, Chen CL, Tao R, Fung JJ, Qian S. Cross-tolerance of recipient-derived transforming growth factor-beta dendritic cells. Transplant Proc. 2007; 39(1): 281-2. IF1.055,已被引用9)

13. Yao Y, Tao R, Wang XM, Jin KL, Sheng XF, Dong W, Xiong SD, Zhu JH, Wang Y, Mao Y, Zhou LF. B7-H1 is correlated with malignancy-grade gliomas but is not expressed exclusively on tumor stem-like cells. Neuro Oncol. 2009;11(6):757-66.IF5.806,已被引用90)

14.Wang L, Tao R, Hancock WW. Using histone deacetylase inhibitors to enhance Foxp3+ regulatory T cell function and induce allograft tolerance. Immunol Cell Biol. 2009; 87(3):195-202 IF4.2,已被引用94 )

15.Tao R, Shapiro R. Successful adult-to-child renal transplantation utilizing the ovarian vein in children with inferior vena cava/iliac vein thrombosis. Pediatr Transplant. 2010 ;14(6):E70-4. .IF1.862, 已被引用11)

16. Wu XB, Tao R, Lei RQ, Han BS, Cheng DF, Shen BY, Peng CH. Distal pancreatectomy combined with celiac axis resection in treatment of carcinoma of the body/tail of the pancreas------A single center experience. Ann Surg Oncol. 2010;17(5):1359-66.IF4.13, 已被引用83次)

17.Tao R, Ruppert K, Cruz RJ Jr, Malik SM, Shaikh O, Ahmad J, DiMartini A, Humar A, Fontes PA, de Vera ME. Hepatitis C recurrence is not adversely affected by the use of donation after cardiac death liver allografts.  Liver Transpl. 2010 Nov;16(11):1288-95.IF: 3.724, 已被引用37次)

18. Wu X, Tao R, Chongpeng P. Distal pancreatectomy combined with celiac axis resection: an alternative approach for some advanced distal pancreatic cancer. Ann Surg Oncol. 2010 Oct 17. IF: 4.13, 已被引用2次)

19. Zhang M, Tao R, Zhang C, Shen Z. Lymphovascular invasion and the presence of more than three tumors are associated with poor outcomes of muscle-invasive bladder cancer after bladder-conserving therapies. Urology. 2010;76:902-7. (IF: 2.365, 已被引用23)

20. Lin XZ, Wu ZY, Tao R, Guo Y, Li JY, Zhang J, Chen KM. Dual energy spectral CT imaging of insulinoma-Value in preoperative diagnosis compared with conventional multi-detector CT. Eur J Radiol. 2012 ;81(10):2487-94. (IF: 2.49, 已被引用102)

21. Wu X, Tao R. Hepatocyte differentiation of mesenchymal stem cells. Hepatobiliary Pancreat Dis Int. 2012; 11:360-71. (IF: 1.181, 已被引用118)

22. Liu XQ, Hu ZQ, Pei YF, Tao R. Clinical operational tolerance in liver transplantation: Current perspective and future prospects. Hepatobiliary Pancreat Dis Int.  2013; 12:12-33. (IF: 1.181, 已被引用31)

23. Li AJ, Zhou WP, Lin C, Lang XL, Wang ZG, Yang XY, Tang QH, Tao R, Wu MC. Surgical treatment of hepatocellular carcinoma with inferior vena cava tumor thrombus: A new classification for surgical guidance. Hepatobiliary Pancreat Dis Int. 2013; 12:263-9. (IF: 1.181, 已被引用36)

24. Yang XY, Xie F, Tao R, Li AJ, Wu MC. Treatment of liver metastases from uveal melanoma: a retrospective single-center analysis. Hepatobiliary Pancreat Dis Int. 2013;12:602-6. (IF: 1.181, 已被引用9)

25. Xin L, Chen QY, Li NJ, Hu ZQ, Zhang Y, Tao R. Self-management and self-efficacy in liver recipients. Hepatobiliary Pancreat Dis Int. 2015;14:253-62 (IF: 1.181,已被引用11)

26. Wang Y, Liu W, Liu X, Sheng M, Pei Y, Lei R, Zhang S, Tao R. Role of liver in modulating the release of inflammatory cytokines involved in lung and multiple organ dysfunction in severe acute pancreatitis. Cell Biochem Biophys. 2015;71(2):76. (IF=2.38, 已被引用30)

27. Wang Y, Fang M, Wang XM, Liu W, Zheng Y, Wu X, Tao R. Proinflammatory effects and molecular mechanisms of interleukin-17 in intestinal epithelial cell line HT-29. World J Gastroenterol. 2014; 20(47):17924-31. (IF=2.433, 已被引用7)

28. Liu X, Hu Z, Zhou B, Li X, Tao R. Chinese herbal preparation Xuebijing potently inhibits inflammasome activation in hepatocytes and ameliorates mouse liver ischemia-reperfusion injury. PLoS One. 2015;10(7):e0131436. (IF=3.234, 已被引用14)

29. 胡志秋,裴耀飞,苏畅,陶然。甲基转移酶抑制剂延长小鼠心脏移植物存活期的作用研究。现代免疫学,2014;已接收。

30. Pei YF, Tao R, Li JF, Su LP, Yu BQ, Wu XY, Yan M, Gu QL, Zhu ZG, Liu BY. TET1 inhibits gastric cancer growth and metastasis by PTEN demethylation and re-expression.

Oncotarget. 2016;7(21):31322-35. (共同第一作者) ( IF: 6.359, 已被引用30)

31. Hu S, Chen M, Wang Y, Wang Z, Pei Y, Fan R, Liu X, Wang L, Zhou J, Zheng S, Zhang T, Lin Y, Zhang M, Tao R, Zhong J. mTOR inhibition attenuates dextran sulfate sodium-induced colitis by suppressing T cell proliferation and balancing TH1/TH17/Treg profile. PLoS One. 2016;11:e0154564. (共同通讯作者) ( IF: 3.234, 已被引用37)

32. Cheng M, Hu S, Wang Z, Pei Y, Fan R, Liu X, Wang L, Zhou J, Zheng S, Zhang T, Lin Y, Zhang M, Tao R, Zhong J. Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation. Oncotarget. 2016;7:35643-35654. (共同通讯作者) ( IF: 6.359, 已被引用13)

33. Liu XQ, Luo GJ, Jiang JB, Ma TH, Lin XZ, Jiang LP, Cheng JL, Tao R. Signaling through hepatocyte vasopressin receptor 1 protects mouse liver from ischemia-reperfusion injury. Oncotarget. 2016;7:69276-69290. ( IF: 6.359, 已被引用10)

34. Liu J, Zhang CW, Hong DF, Tao R, Chen Y, Shang MJ, Zhang YH. Primary hepatic epithelioid angiomyolipoma: A malignant potential tumor which should be recognized. World J Gastroenterol. 2016;22:4908-17. ( IF: 3.365, 已被引用29)

35. Zhou G, Yang Z, Wang X, Tao R, Zhou Y. TRAIL enhances shikonin induced apoptosis through ROS/JNK signaling in cholangiocarcinoma cells. Cell Physiol Biochem. 2017;42:1073-1086. ( IF: 5.5, 已被引用33)

36. Wang X, Wang J, Yu Y, Ma T, Chen P, Zhou B, Tao R. Decitabine inhibits T cell proliferation via a novel TET2-dependent mechanism and exerts potent protective effect in mouse auto- and allo-immunity models. Oncotarget. 2017;8:56802-56815. ( IF: 5.168, 已被引用23)

37. Hu Z, Jiang K, Chang Q, Zhang Y, Zhou B, Zhang Z, Tao R. Effect of Talin1 on apoptosis in hepatoma carcinoma cells via the PI3K/Akt/NF-κB signaling pathway. RSC Adv. 2017; 7(64):40179-40188. ( IF: 3.049, 已被引用5)

38. Yu Y, Qi J, Xiong J, Jiang L, Cui D, He J, Chen P, Li L, Wu X, Ma T, Shao S, Wang J, Yu D, Zhou B, Huang D, Schmitt C, Tao R. Epigenetic co-deregulation of EZH2/TET1 is a senescence-countering, actionable vulnerability in triple-negative breast cancer. Theranostics. 2019; 9(3): 761-777. (IF:8.537, 已被引用17)

39.Shao S, Cui D, Ma C, Chen P, Zhou B, Tao R, Wang J. Transcriptome profiling of tolerogenic dendritic cells conditioned with dual mTOR kinase inhibitor, AZD8055. Int Immunopharmacol. 2020;81:106241. (共同通讯作者) (IF: 3.361, 已被引用2)

40. Hu Z, Lu Y, Cui D, Ma C, Tao R, Wang J. MicroRNAs and Long non-coding RNAs in liver surgery: diagnostic and therapeutic merits. (共同通讯作者) Hepatobiliary Pancreat Dis Int. 2020;19(3):218-228. (IF:2.150, 已被引用1)

41. Qi J, Wang C, Yu Y, Zhao Q, Wu Q, Chen Z, Cui D, Heuberger J, Fang J, Xu R, Birchmeier W, Tao R. TET1 restrains metastatic spreading and EMT by FOXO4-mediated β-catenin inhibition in gastric cancer.  British J Cancer. 2021; revised.


 

研究生带教情况

上海交大医学院 外科学博士生导师

苏州大学医学院 外科学博士生导师

中国医科大学外科学博士生导师


 

最后更新时间:2025-03-31